Effect of the H_2 receptor antagonist lafutidine on neuropathic pain in rats
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概要
- 論文の詳細を見る
We investigated the effect of lafutidine, an H_2 receptor antagonist, on neuropathic pain. To confirm that its antagonistic action against H_2 receptors is not involved in this mechanism, we compared this agent with famotidine. After preparing a neuropathic pain model, we confirmed the onset of neuropathic pain in a behavioral test. The effect of administering lafutidine at 10 or 20mg/kg/day (L10 and L20 groups), famotidine at 3 mg/kg/day (F3 group), and physiological saline (S group), were compared using a behavioral test. Although the agents had no effect in the L10, F3, and S groups, administration significantly improved mechano-allodynia, cold-allodynia, and mechano-hyperalgesia in the L20 group. These findings suggest that lafutidine is effective for neuropathic pain. (J Osaka Dent Univ 2005 ; 39 : 21-25.)
- 大阪歯科学会の論文
著者
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Kotani Junichiro
Department of Anesthesiology, Osaka Dental University
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Kotani Junichiro
Osaka Dental Univ. Osaka Jpn
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Kotani J
Department Of Anesthesiology Osaka Dental University
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Kotani Junichiro
Department Of Anesthesiology Osaka Dental University
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SAKUMA Yasushi
Department of Anesthesiology,Osaka Dental University
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Sakuma Yasushi
Osaka Dental Univ. Osaka Jpn
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Sakuma Yasushi
Department Of Anesthesiology Osaka Dental University
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Kato Yasuhiko
Department of Anesthesiology, Osaka Dental University
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Kan Yuki
Graduate School of Dentistry(Anesthesiology), saka Dental University
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Kan Yuki
Graduate School Of Dentistry (anesthesiology) Osaka Dental University
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Kato Yasuhiko
Department Of Anesthesiology Osaka Dental University
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