Role of the blood-nerve barrier in neuropathic pain and the effect of thalidomide
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概要
- 論文の詳細を見る
We investigated the presence or absence and timing of BNB failure using various neuro pathic pain models : the complete Freund's adjuvant neuritis (CFA) model, the Hashimoto model, the axotomy model, and the chronic constriction nerve injury (CCI) model. In addition, we investigated whether thalidomide inhibited BNB failure. The CFA model did not show BNB failure. However, all rats had BNB failure 21 days after surgery with the Hashimoto model. In the axotomy model, all rats showed BNB failure 14 days after surgery. With the CCI model, they all had BNB failure 12 hours after surgery. Furthermore, administration of thalidomide to the CCI model more markedly inhibited BNB failure at a higher dose or when administration was started earlier.
- 大阪歯科学会の論文
著者
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SAKUMA Yasushi
Department of Anesthesiology,Osaka Dental University
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Sakuma Yasushi
Department Of Anesthesiology Osaka Dental University
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Oka Masaki
Graduate School of Dentistry(Anesthesiology), Osaka Dental University
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Oka Masaki
Graduate School Of Dentistry(anesthesiology) Osaka Dental University
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