Involvement of the NMDA Receptor in Learning and Memory in Rats with Neuropathic Pain
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概要
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It is known that the N-methyl-D-aspartate (NMDA) receptor is important for learning/memory capability and neuropathic pain. Although it has been reported that NMDA receptor antagonists cause learning/memory disorders, they are effective for neuropathic pain. We investigated the relation between the NMDA receptor and learning/memory capability using neuropathic pain chronic constriction injury (CCI) model rats on the 8-arm radial maze and the step-through type passive avoidance apparatus. The CCI model rats performed better on the tests than either the normal animals or those that had received NMDA receptor antagonists. These findings suggest that the neuropathic pain of the CCI rats raised their learning/memory ability through the NMDA receptor.
著者
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Kotani Junichiro
Department of Anesthesiology, Osaka Dental University
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Kotani Junichiro
Osaka Dental Univ. Osaka Jpn
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Kotani Junichiro
Department Of Anesthesiology Osaka Dental University
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SAKUMA Yasushi
Department of Anesthesiology,Osaka Dental University
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Sakuma Yasushi
Osaka Dental Univ. Osaka Jpn
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Sakuma Yasushi
Department Of Anesthesiology Osaka Dental University
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Andoh Taiki
Graduate School of Dentistry (Anesthesiology), Osaka Dental University
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Andoh Taiki
Graduate School Of Dentistry (anesthesiology) Osaka Dental University
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