Involvement of Akt (protein kinase B) in sevoflurane-induced attenuation of cardiac ischemia-reperfusion injury
スポンサーリンク
概要
- 論文の詳細を見る
Volatile anesthetics such as isoflurane and sevoflurane induce cardioprotection mimicking ischemic preconditioning. It has been reported that isoflurane-induced myocardial preconditioning is dependent on phosphatidylinositol-3-kinase (PI 3 K)/Akt signaling which plays a central role in reperfusion injury salvage kinase cascade. It remains unclear whether this signaling cascade is involved in sevoflurane-induced preconditioning. Isolated perfused guinea pig hearts were subjected to 30 min global ischemia and 120 min reperfusion (CTL). Sevoflurane-induced preconditioning was elicited by administration of sevoflurane for 10 min at one minimum alveolar concentration (1 MAC) with 10 min washout before ischemia (SEVO). Contractile recovery was monitored by left ventricular developed pressure (LVDP) and left ventricular end-diastolic pressure (LVEDP). Infarct size (IS) was determined by triphenyltetrazolium chloride (TTC) stain. Phosphorylation of Akt, a downstream target of PI 3 K, was assessed by western blot. After ischemia-reperfusion, SEVO had higher LVDP and lower LVEDP versus CTL. Infarct size was significantly reduced in SEVO compared to CTL (44±8% versus 23±7%). Akt phosphorylation was not increased during ischemia or at 10 min after reperfusion, which is in contrast to the findings previously demonstrated in isoflurane-induced preconditioning. Other reperfusion injury salvage kinases, such as mitogen-activated protein kinase/extra-cellular signal-regulated kinases (MEK) and extra-cellular signal-regulated kinase (ERK), may be more important in sevoflurane-induced preconditioning. (J Osaka Dent Univ 2007 ; 41 : 151-159)
- 大阪歯科学会の論文
著者
-
Kotani Junichiro
Department of Anesthesiology, Osaka Dental University
-
Kotani Junichiro
Osaka Dental Univ. Osaka Jpn
-
Kotani J
Department Of Anesthesiology Osaka Dental University
-
Kotani Junichiro
Department Of Anesthesiology Osaka Dental University
-
Miyamae Masami
Department of Internal Medicine, Osaka Dental University
-
Kaneda Kazuhiro
Graduate School, Dentistry (Department of Anesthesiology), Osaka Dental University
-
Miyamae Masami
Department Of Internal Medicine Osaka Dental University
-
Kaneda Kazuhiro
Department Of Anesthesiology Osaka Dental University
-
Kaneda Kazuhiro
Graduate School of Pure and Applied Sciences, University of Tsukuba, Tsukuba, Ibaraki 305-8573, Japan
関連論文
- Involvement of the NMDA Receptor in Learning and Memory in Rats with Neuropathic Pain
- Intra-articular pressure-volume index (IAPVI) for diagnosis of internal derangement of the temporomandibular joint
- Acute Morphological Changes in the Upper Airway after Osteotomy for Skeletal Mandibular Prognathism
- Apoptotic cells in pleomorphic adenomas
- Bone Regeneration Using Dedifferentiated Fat Cells with PuraMatrix^
- Effect of propofol on vascular absorption of local anesthetics containing adrenalin
- Effect of hyperventilation on organ tissue blood flow in brain and ventricles of rabbits measured by the colored microsphere method
- Cerebral circulation immediately before and during electroencephalographic convulsive activity induced by continuous intravenous administration of lidocaine in rabbits : Comparison with pentylenetetrazole and picrotoxin
- Study on Guidelines for Safe Intravenous Sedation
- Effect of nitric oxide on cerebrospinal fluid dynamics
- Development of cerebral edema and changes in autoregulation of cerebral blood flow caused by regional cerebral venous infarction in rabbits
- Autoregulation during focal cerebral ischemia under sevoflurane anesthesia in rats
- Intraventricular administration of orexin A evokes waking EEG patterns in rats anesthetized with sevoflurane
- Effects of premedication on salivary secretion in the rat submandibular gland
- Goshajinkigan improves paclitaxel-induced peripheral neuropathy in rats
- Behavioral and histological study of peripheral nerve disorders using an animal model
- Histological study of a paclitaxel-induced peripheral neuropathy model treated with goshajinkigan
- Histological examination of peripheral neuropathy caused by paclitaxel
- Role of the internal jugular venous valve during an increase in intrathoracic pressure
- Flinching in phase 2 of the formalin test using rat neuropathic pain models
- A case of successful registration of interocclusal relation for a patient with oral dyskinesia using nitrous oxide and oxygen
- Activation of extracellular signal-regulated kinase after ischemia-reperfusion is required for cardioprotection of sevoflurane-induced preconditioning
- Involvement of Akt (protein kinase B) in sevoflurane-induced attenuation of cardiac ischemia-reperfusion injury
- Involvement of free radicals in neuropathic pain and the effect of the free radical scavenger
- Effect of lafutidine on inflammatory pain
- Effect of the H_2 receptor antagonist lafutidine on neuropathic pain in rats
- Effect of different suture materials on the chronic constriction injury model
- A rat paclitaxel model does not develop thermal hyperalgesia
- Effect of systemically and topically administered tetrodotoxin on neuropathic pain
- Electrical Resistivity of YFe_2O_4
- Seebeck Coefficient of YFe_2O_4 at Lower Transition Temperature
- Magnetic Susceptibility of Li_Ti_O_4 Doped with Vanadium
- Cell Viability Test for Alkalinized Lidocaine using the Three-dimensional Cultured Human Skin Model
- Anaphylactic Reaction Induced by Diclofenac : A Case Report
- Sevoflurane postconditioning prevents activation of caspase 3 and 9 through antiapoptotic signaling after myocardial ischemia-reperfusion
- Comparison of Parker-tipped and Murphy-tipped tracheal tubes in Airway Scope-assisted intubation in a manikin
- Trigeminovagal Reflex Caused by Stimulation of the Mandibular Division of the Trigeminal Nerve under General Anesthesia : A Case Report
- Semiconducting Properties of Li_Ti_O_4
- Morphological Changes in the Pre- and Postoperative Upper Airway in a Case of Microgenia Treated by Mandibular Ramus Distraction Osteogenesis
- Electronic Structure in Valence Band of Nd-Substituted Bi4Ti3O12 Single Crystal Probed by Soft-X-Ray Emission Spectroscopy
- Influences of molar loss of rat on learning and memory
- Elastic Properties of Lithium Germanate Glasses Studied by Brillouin Scattering
- CT scans and MRI of a calcifying epithelial odontogenic tumor (Pindborg tumor)
- Mechanical characteristics of bending in endotracheal tubes
- Sputum viscosity does not affect flow resistance in a heat and moisture exchange filter
- Lidocaine protects against myocardial ischemia-reperfusion injury in anesthetized rabbits
- Analysis of respiratory state and accessory inspiratory muscle activity by spike count processing of surface electromyogram
- Utilizing detector tubes to measure the air concentration of inhalation anesthetics
- Influences of molar loss of rat on learning and memory