Histological examination of peripheral neuropathy caused by paclitaxel

概要

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Although paclitaxel is an effective anticancer drug for treatment of gynecologic cancer, it is associated with peripheral neuropathy. Using a rat model of continuous administration of paclitaxel directly to the sciatic nerve (paclitaxel model), we investigated the mechanism of neuropathic pain by histologically examining the sciatic nerve. Male Sprague-Dawley rats were divided into six groups : the local administration group consisting of the paclitaxel group and the saline group ; the systemic administration group consisting of the 4 mg/kg paclitaxel group, the 8 mg/kg paclitaxel group, and the saline group ; and the control group. One, two, three and four weeks after surgery, sciatic nerve sections were prepared and observed under a light microscope. In addition, the number of myelinated nerve fibers per unit area was calculated, and the ratios of small-diameter to largediameter nerve fibers were compared. The local paclitaxel group showed features of segmental demyelination, such as a marked decrease in large-diameter myelinated nerve fibers, thinning and destruction of myelin sheaths, and atrophy of axons. These changes were caused by the direct action of paclitaxel on the nerve, indicating that the paclitaxel model is an animal model of segmental demyelination.
大阪歯科学会の論文