Effect of systemically and topically administered tetrodotoxin on neuropathic pain

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We administered tetrodotoxin (TTX) to the rat neuropathic pain model, and investigated changes in neuropathic pain behavior. One hour after administration by intraperitoneal injection of 1 μg/kg, the mechanical hyperesthesia response time was prolonged compared to the pretreatment value, indicating exacerbation of symptoms. In contrast, the response time was shortened one hour after intraperitoneal administration of TTX at 3μg/kg, indicating improvement in the symptoms. Intraperitoneal injection of both 1μg/kg and 3μg/kg prolonged the cold allodynia response time one hour after administration compared to the pretreatment value. However, three hours after administration, the response time was shortened for the 3μg/kg dose. Administration of 1 ng/kg teirodotoxin in the main sciatic nerve improved cold allodynia for four days. Both systemic and local administration improved neuropathic pain behavior. Therefore, tetrodotoxin-sensitive sodium channels should be further investigated.(J Osaka Dent Univ 2003; 37: 99-102.)
大阪歯科学会の論文