Effect of cilostazol on two neuropathy models using the formalin test

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We studied the effects of cilostazol on diabetic and chronic constriction injury (CCI) neuropathy using the formalin test. Cilostazol increased blood flow to the nerves, and seemed to improve CCI and diabetic neuropathy by decreasing ischemia and hypoxia. Although flinching increased during all phases under CCI neuropathy, cilostazol caused a greater increase during phase Q than in other phases. CCI neuropathy may decrease the response of nociceptors. Although animals show self-nocifensor in phase Q, we did not find this in our study. Under diabetic neuropathy, flinching increased in phases 1 and Q. Cilostazol tended to suppress flinching in diabetic rats. Cilostazol may suppress activation of C fibers and substance P discharge. We found no significant changes in phase 2. Cilostazol may have no effect on inflammatory pain. The CCI model, which is related to causalgia, and the diabetic model, which is related to diabetic neuropathy, may be useful in future clinical studies.
大阪歯科学会の論文