Intraventricular administration of orexin A evokes waking EEG patterns in rats anesthetized with sevoflurane
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概要
- 論文の詳細を見る
How the orexins, which are neuropeptides that play an important role in maintaining wakefulness, modulate the hypnotic effect of general anesthetics is not well understood. We administered orexin A to rats under sevoflurane anesthesia to investigate its effect on the electroencephalogram (EEG), cerebral blood flow (CBF), and mean arterial pressure (MAP). After confirmation of the presence of burst suppression patterns by EEG, rats anesthetized with 3% sevoflurane received intraventricular administration of orexin A at 1nmol/5μL. We observed changes in EEG, CBF, and MAP before and after the admini-stration. Burst suppression patterns on the EEG disappeared in some rats and the frequency of bursts was increased in others. CBF was increased after administration of orexin A. It is believed that orexin nerves activate the brainstem, which regulates sleep and wakefulness. The induction of waking EEG patterns by intraventricular administration of orexin A indicates that it modulates the anesthetic effect of sevoflurane.
- 大阪歯科学会の論文
著者
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Kotani Junichiro
Department of Anesthesiology, Osaka Dental University
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Kotani Junichiro
Department Of Anesthesiology Osaka Dental University
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MATSUDA Yoshiko
Department of Pediatrics, Osaka University Faculty of Medicine
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Kano Seiji
Department Of Anesthesiology Osaka Dental University
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Yamabayashi Kazutomo
Department of Anesthesiology, Osaka Dental University
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Taniwa Satoko
Graduate School, Dentistry (Department of Anesthesiology), Osaka Dental University
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Taniwa Satoko
Graduate School Dentistry (department Of Anesthesiology) Osaka Dental University
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Matsuda Yoshiko
Department Of Anesthesiology Osaka Dental University
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Yamabayashi Kazutomo
Department Of Anesthesiology Osaka Dental University
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