Changes in the electroencephalogram caused by intravenous administration of modafinil under sevoflurane anesthesia in rats
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概要
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Modafinil, a drug for the treatment of hypersomnia and narcolepsy, activates dopaminergic neurons and histaminergic neurons and inhibits the release of gamma-aminobutyric acid to enhance awakening from natural sleep. However, it is unclear whether modafinil modulates the hypnotic effects of volatile anesthetics. We therefore investigated the effects of intravenous modafinil on the depth of anesthesia in rats under sevoflurane anesthesia by evaluating the spectral edge frequency 95% (SEF95) of the electroencephalogram. Modafinil at various doses did not induce changes in SEF95 in animals anesthetized with a fixed concentration of sevoflurane. The absence of inhibition of the hypnotic effect of sevoflurane suggests that modafinil targets areas in the brain that are not involved in awakening from natural sleep.
著者
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Kano Seiji
Department Of Anesthesiology Osaka Dental University
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Matsuda Yoshiko
Department Of Anesthesiology Osaka Dental University
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Kotani Junihciro
Department Of Anesthesiology Osaka Dental University
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