<研究論文抄録>新規強力抗腫瘍薬および胃液分泌抑制薬, (-)-cis-2,3-Dihydro-3-(4-methylpiperazinylmethyl)-2-phenyl-1,5-benzothiazepin-4(5H)-one Hydrochloride(BTM-1086), および関連化合物の合成
スポンサーリンク
概要
著者
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堀 幹夫
Gifu Pharmaceutical University
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大野 左千雄
Research Laboratories, Maruko Seiyaku Co., Ltd.,
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水越 清史
Research Laboratories, Maruko Seiyaku Co., Ltd.,
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水越 清史
Research Laboratories Maruko Seiyaku Co. Ltd.
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泉 喜八郎
Research Laboratories, Maruko Pharmaceutical Co., Ltd.,
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加藤 和雄
Research Laboratories, Maruko Pharmaceutical Co., Ltd.,
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大野 左千雄
マルコ製薬研究所
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泉 喜八郎
マルコ製薬研究所
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水越 清史
マルコ製薬研究所
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加藤 和雄
マルコ製薬研究所
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加藤 和雄
Research Laboratories Maruko Pharmaceutical Co. Ltd.
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大野 左千雄
Research Laboratories Maruko Seiyaku Co. Ltd.
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大野 佐千雄
Research Laboratories Maruko Pharmaceutical Co. Ltd.
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泉 喜八郎
Research Laboratories Maruko Pharmaceutical Co. Ltd.
関連論文
- Generation and Alkylation of α-Lithio-Se, O-heteroacetals, and Stereoselective Cyclization of Olefinic Se, O-Heteroacetals
- Reactions of 9-Phenylthioxanthene 10-Oxide with Organometallic Reagents
- Synthesis and Reactions of 10-Chloro-10,9-(epoxyalkano)selenoxanthenes and 1-Chloro-1-phenyl-3H-2,1-benzoxaselenoles
- 2-Methylisoselenochromanium Salts : Spectroscopic Properties and Reactions
- Synthesis of 2,6-Epithio-3-benzazocine Derivatives
- Facile Synthesis of 8-Benzoylthio-2,6-methano-3-benzazocines and 3-Benzoylthiomorphinans Having Small-Ring Substituents
- Synthesis and Analgetic Activity of Sulfur-Containing Morphinans and Related Compounds
- Synthesis and Reactions of 1-Thianaphthalenes
- Synthesis and thermal Reactions of Cyano-Stabilized Cyclic Sulfur Ylides, 2-Alkyl-1-cyano-3,4-dihydro-1H-2-thionianaphthalen-1-ides
- チアベンゼンと関連環状硫黄イリド類--合成とその多様な反応性
- Ring Contraction of 2-Chlorocyclohexanone with Grignard Reagents
- Generation and Properties of N^7-Xanthinium Ylides : Reactions of N^7-Xanthinium Ylides with Diphenylcyclopropenone and Acetylenic Compounds
- Reactions of 8,9-Dihydroxanthines with Acetylenic Compounds. Formation of Heteropropellanes
- 10-Alkyl-9-arylthioxathenium Salt類の合成と立体化学
- 1,4-イリド性Thiaanthracenesの新規転位反応
- Synthesis and Analgesic Activity of Novel Heterocycles, [1]Benzothiopyrano[3,4-b]pyrrole Derivatives
- Synthesis of Some N-Substituted 1,2,3,4,5,6-Hexahydro-2,6-methano-3-benzazocines (6,7-Benzomorphans)
- 5,7-Ethano-4,5,5a, 6,7,1lb-hexa-hydro-2,6,7-trimethyl-1H-benzo[g]homoquinolin-9-01 and 4,6-Ethano-3,4,4a, 5,6,10b-hexahydro-2,5,6-trimethylbenzo[f]quinolin-8-olのアゴニスト-アンタゴニスト性
- AGONIST-ANTAGONIST PROPERTIES OF 5,7-ETHANO-4,5,5a, 6,7,11b-HEXAHYDRO-2,6,7-TRIMETHYL-1H-BENZO [g] HOMOQUINOLIN-9-OL AND 4,6-ETHANO-3,4,4a, 5,6,10b-HEXAHYDRO-2,5,6-TRIMETHYLBENZO [f] QUINOLIN-8-OL
- Sulfur-Containing Acylamino Acids. II. Syntheses and Angiotensin I Converting Enzyme-Inhibitory Activities of N-Mercaptoal-kanoyl-S-ethyl-L-cysteine(Medicinal Chemistry,Chemical)
- Sulfur-Containing Acylamino Acids. I. Syntheses and Angiotensin I Converting Enzyme-Inhibitory Activities of Sulfur-Containing N-Mercaptoalkanoyl Amino Acids(Medicinal Chemistry,Chemical)
- Studies on Benzothiazoline Derivatives. IV. Synthesis and Novel Ring Expansion Reaction of Benzothiazoline Sulfoxides
- Studies on Benzothiazoline Derivatives. III. Reactions of 2,2-Disubstituted Benzothiazolines with Haloacyl Halides or Acid Anhydrides
- A New Aspect on Alkylation of Benzothiazolines
- 新規なHalosulfuranes, 5-Chloro-および5-Bromo-5,11-epoxy-6,11-dihydrodibenzo[b, e]thiepinの合成と構造
- 新規な双環セレヌラン類 : 10-Chloro-10,9-epoxyethanoselenoxanthenes類の合成と性質
- Selenoxanthen-10-io(alkoxalyl alkoxycarbonyl)methanide類および関連化合物の合成, 立体化学ならびに反応
- Synthesis, Stereochemistry and Reactions of Selenoxanthen-10-io (alkoxalyl alkoxycarbonyl) methanides and Related Compounds
- cisおよびtrans-9-Phenylselenoxanthene-N-arylsulfonyl-selenilimine類の化学
- Xanthinium N(7)-Ylide類とトランスオレフンィン型Dipolarophile類の付加環化反応
- 安定な2-Thianaphthalene誘導体の新規な1,4-環化付加反応 : 3-Benzoyl-la, 2-dimethoxycarbonyl-1-methylthio-la, 7b-dihydrocyclopropa[a]-naphthaleneの生成とX-線結晶構造
- Synthesis and Hypoglycemic Activity of 7,8-Dihydro-6H-thiopyrano[3,2-d]pyrimidine Derivatives and Related Compounds
- Synthesis of Asymmetric 4-Aryl-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylates with Vasodilating and Antihypertensive Activities
- 新規含硫黄鎮痛薬S-Etorphineの合成
- 麻薬性鎮痛薬(1,2-Diphenylethyl)piperazines : 絶対配置と麻薬受容体親和性における特異な相関性
- 2-Alkyl (or Aryl)-1-benzoyl-3,4-dihydro-1H-2-thionianaphthalen-1-ide類と酸性水素をもつ化合物との熱反応
- SYNTHESIS OF THE NOVEL SULFUR-CONTAINING ANALGESIC S-ETORPHINE
- Dibenzothiophenes and Related Compounds. IV. Reactions of 5-Substituted 10,11-Dihydrodibenzo [b, f] thiepinium Salts with Aryllithiums
- 環状硫黄イリド類の熱反応の新様式
- Studies on the Syntheses of Analgesics. VI. Synthesis of 1,2,3,4,5,6-Hexahydro-1,5-methano-3-benzazocine Derivatives
- Studies on the Syntheses of Analgesics. IV. Syntheses of 1,2,3,4-Tetrahydro-5H-benzazepine Derivatives
- Synthesis and Structure-Activity Relationships of New (5R, 8S, 10R)-Ergoline Derivatives with Antihypertensive or Dopaminergic Activity
- Synthesis and Structure-Activity Relationships of New (5R, 8R, 10R)-Ergoline Derivatives with Antihypertensive or Dopaminergic Activity
- Synthesis of 2-Aryl-2,3-dihydro-3-piperazinylmethyl-1,5-benzothiazepin-4(5H)-ones and Related Compounds
- 新規強力抗腫瘍薬および胃液分泌抑制薬, (-)-cis-2,3-Dihydro-3-(4-methylpiperazinylmethyl)-2-phenyl-1,5-benzothiazepin-4(5H)-one Hydrochloride(BTM-1086), および関連化合物の合成
- SYNTHESIS OF A NEW POTENT ANTI-ULCER AND GASTRIC SECRETORY INHIBITING AGENT, (-)-cis-2,3-DIHIDRO-3-(4-METHYLPIPERAZINYLMETHYL)-2-PHENYL-1,5-BENZOTHIAZEPIN-4 (5H)-ONE HYDROCHLORIDE (BTM-1086), AND RELATED COMPOUNDS
- PyrazoloneおよびPyrazole誘導体の合成研究(第5報) : 5-Alkoxy-3-(N-substituted Carbamoyl)-1-substituted Phenylpyrazole誘導体の合成
- 新規環状スルフィルイミン類, 2-Azathiabenzene誘導体の合成と諸性質
- A Novel Ring System, α-Thieno [4,3-f] morphan
- Thiabenzene誘導体のX線結晶構造
- PyrazoloneおよびPyrazole誘導体の合成研究(第6報) : 1-(3-Chlorophenyl)-3-(N, N-dimethylcarbamoyl)-5-methoxypyrazole投与ウサギ尿中代謝物の単離と同定
- PyrazoloneおよびPyrazole誘導体の合成研究(第6報)1-(3-Chlorophenyl)-3-(N, N-dimethylcarbamoyl)-5-methoxypyrazole投与ウサギ尿中代謝物の単離と同定
- Reactivities of 9-Phenylxanthylium and 9-Phenylthioxanthylium Salts in Electrophilic and Nucleophilic Reactions. I. Nitration
- 10-Thiaanthracenes. I. Mechanism of the Reaction of 3-Phenylthioxanthylium Salt with Organometallic Reagents
- Dibenzothiophenes and Related Compounds. VI. Reactions of Cyclic Sulfonium Salts with Sodium Alkoxides and Benzenethiolate in Alcohols
- Dibenzothiophenes and Related Compounds. V. Reactions of 5-Substituted Dibenzothiophenium Salts with Organometallic Reagents
- Dibenzothiophenes and Related Compounds. III. Reactions of 10-Substituted 9,9-Dimethylthioxanthenium and 5-Substituted Dibenzothiophenium Salts with Organolithiums
- Dibenzothiophenes and Related Compounds. II. Reactions of 5-Substituted Dibenzothiophenium Salts with Organolithiums
- 非麻薬性強力鎮痛薬の合成研究
- オクテット
- 最初の結晶性 1.4-イリド, 9-cyano-10-methyl-10-thiaanthraceneの合成と性質
- PyrazoloneおよびPyrazole誘導体の合成研究(第3報)3-Substituted 5-Methoxy-1-phenylpyrazole誘導体の合成
- Studies on the Syntheses of Analgesics. V. Synthesis of 1,2,3,4,5,6-Hexahydro-3-benzazocine Derivatives. (3)
- 9-Arylthioxanthene 10-0xides類および10,10-Dioxide類の立体化学
- Stereochemistry of 9-Arylthioxanthene 10-Oxides and 10,10-Dioxides
- PyrazoloneおよびPyrazole誘導体の合成研究(第7報) : Ethyl 5-Allyloxy-1-phenylpyrazole-3-carboxylateのClaisen転位
- 結晶性最初のThiaanthracene類, 9-Cyno-および9-(Ethoxycarbonyl)-10-thiaanthraceneの合成ならびに親電子試薬類との反応
- PyrazoloneおよびPyrazole誘導体の合成研究(第7報)Ethyl 5-Allyloxy-1-phenylpyrazole-3-carboxylateのClaisen転位
- 10-Alkyl-9-arylthioxanthenium Saltsの立体化学
- 9-Arylthioxanthene 10-Oxidesおよび10,10-Dioxidesの立体化学
- 1,4-イリド性チアアントラセン類の新しいラジカル転位反応
- Stable S-Alkylthiabenzenes. Synthesis of 2-Methyl-1-phenyl-2-thianaphthalene
- A New Synthesis of S-Arylthiabenzene Analogues using Grignard Reaction
- チアベンゼンと関連環状硫黄イリド類 : 合成とその多様な反応性
- Dibenzothiepin Derivatives and Related Compounds. V. Reactions of 6,11-Dihydrodibenzo [b, e] thiepin 5-Oxides with SbCl_5 and Perchloric Acid
- Dibenzothiepin Derivatives and Related Compounds. II. A Novel Cyclization Reaction of 6-Chloro-11-phenyl-6,11-dihydrodibenzo [b, e] thiepins
- A MODIFIED MANNICH REACTION USING 1,3-DIOXOLANE
- PyrazoloneおよびPyrazole誘導体の合成研究(第2報)3位に官能基を有するPyrazole誘導体の合成
- PyrazoloneおよびPyrazole誘導体の合成研究(第1報)3位に官能基を有するPyrazolone誘導体の合成
- 環状スルホニウムイリド類 : 2-Alkyl(or aryl)-1-benzoyl-1H-2-thianaphthalen-2-ium-1-idesおよび2-Alkyl(or aryl)-1-benzoyl-3,4-dihydro-1H-2-thianaphthalen-2-ium-1-idesの合成と熱反応
- Syntheses and Properties of Novel Cyclic Sulfilimines, 2-Azathiabenzene Derivatives
- Benzothiazoline Sulfoxide類の非立体特異的環拡大反応
- 5員複素環状スルホキシド類の非立体特異的環拡大反応
- 7員複素環状スルホキシド類, 2,2-ジ置換 1,4-および1,5-Benzothiazepine Sulfoxide類の環変換反応
- Non-stereospecific Ring Expansion Reactions of Benzothiazoline Sulfoxides
- Syntheses and Cycloaddition Reactions of Thiaazulenocyclone and Thiaazulenocyclone 8,8-Dioxide
- Selenoxanthylium Salts. I. Nitration of 9-Phenylselenoxanthylium Perchlorate
- Selenabenzenes. I. Synthesis of 10-Selenaanthracene Derivatives