Studies on Benzothiazoline Derivatives. III. Reactions of 2,2-Disubstituted Benzothiazolines with Haloacyl Halides or Acid Anhydrides
スポンサーリンク
概要
- 論文の詳細を見る
A new ring transformation of benzothiazolines to 3-oxo-2,3-dihydro-4H-1,4-benzothiazines or benzothiazoles was found in the reactions of 2,2-disubstituted benzothiazolines (3-5) with haloacyl halides. N, S-Bis (haloacyl) o-aminobenzenethiols were key intermediates of the reactions. In the case of benzothiazoline (1) and 2-methylbenzothiazoline (2), N-acylated products were obtained. Reactions with acid chlorides or acid anhydrides gave the N-acylated compounds in good yields.
- 社団法人日本薬学会の論文
- 1979-09-25
著者
-
片岡 貞
岐阜薬科大学薬化学講座
-
片岡 貞
Gifu Pharmaceutical University
-
清水 洋
Gifu Pharmaceutical University
-
堀 幹夫
Gifu Pharmaceutical University
-
今井 豊
Gifu College of Pharmacy
関連論文
- 6,14-Ethenomorphine類の合成と腫瘍細胞増殖抑制作用
- アルキニルおよびアルケニルセレノニウム塩の反応性と有用な合成素子としての活用
- 電子求引基で安定化されたセレナベンゼンの合成に関する研究
- 肝細胞増殖因子の細胞運動促進作用発現のシグナル系におけるMAPキナーゼ活性化の役割
- Generation of Selenabenzenes Bearing an Electron-Withdrawing Group at the 2-Position
- Generation and Alkylation of α-Lithio-Se, O-heteroacetals, and Stereoselective Cyclization of Olefinic Se, O-Heteroacetals
- Reactions of 9-Phenylthioxanthene 10-Oxide with Organometallic Reagents
- Synthesis and Reactions of 10-Chloro-10,9-(epoxyalkano)selenoxanthenes and 1-Chloro-1-phenyl-3H-2,1-benzoxaselenoles
- 2-Methylisoselenochromanium Salts : Spectroscopic Properties and Reactions
- Synthesis of 2,6-Epithio-3-benzazocine Derivatives
- Facile Synthesis of 8-Benzoylthio-2,6-methano-3-benzazocines and 3-Benzoylthiomorphinans Having Small-Ring Substituents
- Synthesis and Analgetic Activity of Sulfur-Containing Morphinans and Related Compounds
- Synthesis and Reactions of 1-Thianaphthalenes
- Synthesis and thermal Reactions of Cyano-Stabilized Cyclic Sulfur Ylides, 2-Alkyl-1-cyano-3,4-dihydro-1H-2-thionianaphthalen-1-ides
- チアベンゼンと関連環状硫黄イリド類--合成とその多様な反応性
- Ring Contraction of 2-Chlorocyclohexanone with Grignard Reagents
- Generation and Properties of N^7-Xanthinium Ylides : Reactions of N^7-Xanthinium Ylides with Diphenylcyclopropenone and Acetylenic Compounds
- Reactions of 8,9-Dihydroxanthines with Acetylenic Compounds. Formation of Heteropropellanes
- 10-Alkyl-9-arylthioxathenium Salt類の合成と立体化学
- 1,4-イリド性Thiaanthracenesの新規転位反応
- Synthesis of Some N-Substituted 1,2,3,4,5,6-Hexahydro-2,6-methano-3-benzazocines (6,7-Benzomorphans)
- 5,7-Ethano-4,5,5a, 6,7,1lb-hexa-hydro-2,6,7-trimethyl-1H-benzo[g]homoquinolin-9-01 and 4,6-Ethano-3,4,4a, 5,6,10b-hexahydro-2,5,6-trimethylbenzo[f]quinolin-8-olのアゴニスト-アンタゴニスト性
- 5,7-Ethano-4,5,5a, 6,7,1lb-hexahydro-2,6,7-trimethyl-1H-benzo[g]homoquinolin-9-olと4,6-Ethano-3,4,4a, 5,6,10b-hexahydro-2,5,6-trimethylbenzo[f]quinolin-8-olの合成
- AGONIST-ANTAGONIST PROPERTIES OF 5,7-ETHANO-4,5,5a, 6,7,11b-HEXAHYDRO-2,6,7-TRIMETHYL-1H-BENZO [g] HOMOQUINOLIN-9-OL AND 4,6-ETHANO-3,4,4a, 5,6,10b-HEXAHYDRO-2,5,6-TRIMETHYLBENZO [f] QUINOLIN-8-OL
- Benzothiazoline誘導体に関する研究(第4報) : Benzothiazoline Sulfoxide類の合成と新規な環拡大反応
- Benzothiazoline sulfoxide類の新規な環変換反応
- Benzothiazoline類の3-Oxo-2,3-dihydro-4H-1,4-benzothiazine類あるいはBenzothiazole類への新規な環変換反応
- Benzothiazoline誘導体に関する研究(第2報) : 2位および3位に置換基を有するBenzothiazoline誘導体の合成
- Studies on Benzothiazoline Derivatives. IV. Synthesis and Novel Ring Expansion Reaction of Benzothiazoline Sulfoxides
- Studies on Benzothiazoline Derivatives. III. Reactions of 2,2-Disubstituted Benzothiazolines with Haloacyl Halides or Acid Anhydrides
- A New Aspect on Alkylation of Benzothiazolines
- Benzothiazoline誘導体に関する研究(第1報)2-Aryl-3-methylbenzothiazoline類の合成とその酸化開環反応
- 新規なHalosulfuranes, 5-Chloro-および5-Bromo-5,11-epoxy-6,11-dihydrodibenzo[b, e]thiepinの合成と構造
- 新規な双環セレヌラン類 : 10-Chloro-10,9-epoxyethanoselenoxanthenes類の合成と性質
- Selenoxanthen-10-io(alkoxalyl alkoxycarbonyl)methanide類および関連化合物の合成, 立体化学ならびに反応
- Synthesis, Stereochemistry and Reactions of Selenoxanthen-10-io (alkoxalyl alkoxycarbonyl) methanides and Related Compounds
- cisおよびtrans-9-Phenylselenoxanthene-N-arylsulfonyl-selenilimine類の化学
- 安定なSelenoxanthenium Ylide類 : Selenoxanthen-10-io(alkoxalyl alkoxycarbonyl)methanide類ならびにその関連化合物の合成と新しい還元的環化反応
- セレニルイミン類の立体異性体 : 9-Phenylselenoxanthene-N-arylsulfonylselenilimine類の単離と反応
- Xanthinium N(7)-Ylide類とトランスオレフンィン型Dipolarophile類の付加環化反応
- 新規なキサンチニウムイリド類の環変換反応
- Xanthine誘導体の新規な環変換反応
- 新環状硫黄イリド類, 8-Thiaazulenesと求電子試薬の反応
- 安定な2-Thianaphthalene誘導体の新規な1,4-環化付加反応 : 3-Benzoyl-la, 2-dimethoxycarbonyl-1-methylthio-la, 7b-dihydrocyclopropa[a]-naphthaleneの生成とX-線結晶構造
- 新規含硫黄鎮痛薬S-Etorphineの合成
- 2-Alkyl (or Aryl)-1-benzoyl-3,4-dihydro-1H-2-thionianaphthalen-1-ide類と酸性水素をもつ化合物との熱反応
- SYNTHESIS OF THE NOVEL SULFUR-CONTAINING ANALGESIC S-ETORPHINE
- 1-Benzoyl-2-methyl-3,4-dihydro-2-thianaphthaleneと酸性水素を持つ化合物との新規な反応
- カルコゲン官能基を有するα,β-不飽和カルボニル化合物と求電子剤の連結反応
- Dibenzothiophenes and Related Compounds. IV. Reactions of 5-Substituted 10,11-Dihydrodibenzo [b, f] thiepinium Salts with Aryllithiums
- 環状硫黄イリド類の熱反応の新様式
- 新規環状スルフィルイミン類, 2-Azathiabenzene誘導体の合成と諸性質
- 10-Thiaanthracenes類(第2報)9-Alkoxyphenyl-および9-Aryloxyphenyl-10-phenyl-10-thiaanthracene類の合成
- Thiabenzene誘導体のX線結晶構造
- Reactivities of 9-Phenylxanthylium and 9-Phenylthioxanthylium Salts in Electrophilic and Nucleophilic Reactions. I. Nitration
- 10-Thiaanthracenes. I. Mechanism of the Reaction of 3-Phenylthioxanthylium Salt with Organometallic Reagents
- Reactivities of 9-Phenylxanthylium and 9-Phenylthioxanthylium Salts in Electrophilic and Nucleophilic Reactions. III
- Dibenzothiophenes and Related Compounds. VI. Reactions of Cyclic Sulfonium Salts with Sodium Alkoxides and Benzenethiolate in Alcohols
- Dibenzothiophenes and Related Compounds. V. Reactions of 5-Substituted Dibenzothiophenium Salts with Organometallic Reagents
- Dibenzothiophenes and Related Compounds. III. Reactions of 10-Substituted 9,9-Dimethylthioxanthenium and 5-Substituted Dibenzothiophenium Salts with Organolithiums
- Dibenzothiophenes and Related Compounds. II. Reactions of 5-Substituted Dibenzothiophenium Salts with Organolithiums
- Dibenzothiophene類とその関連化合物に関する研究(第1報)5-Substituted Dibenzothiophenium Salt類ならびに10-Substituted 9,9-Dimethylthioxanthenium Salt類の合成
- 最初の結晶性 1.4-イリド, 9-cyano-10-methyl-10-thiaanthraceneの合成と性質
- 9-Arylthioxanthene 10-0xides類および10,10-Dioxide類の立体化学
- Stereochemistry of 9-Arylthioxanthene 10-Oxides and 10,10-Dioxides
- 結晶性最初のThiaanthracene類, 9-Cyno-および9-(Ethoxycarbonyl)-10-thiaanthraceneの合成ならびに親電子試薬類との反応
- 10-Alkyl-9-arylthioxanthenium Saltsの立体化学
- 9-Arylthioxanthene 10-Oxidesおよび10,10-Dioxidesの立体化学
- 1,4-イリド性チアアントラセン類の新しいラジカル転位反応
- 新型π-ドナーの合成と電荷移動錯体の形成
- Stable S-Alkylthiabenzenes. Synthesis of 2-Methyl-1-phenyl-2-thianaphthalene
- A New Synthesis of S-Arylthiabenzene Analogues using Grignard Reaction
- チアベンゼンと関連環状硫黄イリド類 : 合成とその多様な反応性
- Thiabenzene類の再検討 : 9-Phenylthioxanthylium SaltとPhenyllithiumの反応の新結果
- Dibenzothiepin誘導体およびその関連化合物(第5報) : 6,11-Dihydrodibenzo[b, e]thiepin-5-Oxide類とSbCl_5および過塩素酸の反応
- Dibenzothiepin誘導体およびその関連化合物(第4報) : 諸種Cyclic Ketone類および6,11-Dihydrodibenzo[b, e]thiepin-11-one類とSbCl_5の反応
- Dibenzothiepin誘導体およびその関連化合物(第3報) : Triphenylmethyl Hexachloroantimonateの反応性の研究と6,11-Dohydrodibenzo[b, e]-thiepin-11-ylium Hexachloroanmonate類の合成
- Dibenzothiepin誘導体およびその関連化合物に関する研究 II. : 6-Chloro-11-phenyl-6,11-dihydrodibenzo[b, e]thiepin類の新規な環化反応
- Dibenzothiepin誘導体およびその関連化合物(第1報) : 11-Phenyl-6,11-dihydrodibenzo[b, e]thiepin-11-ylium Saly類の単離とその新規な脱水素環化反応
- Dibenzothiepin誘導体およびその関連化合物(第4報)諸種Cyclic Ketone類および6,11-Dihydrodibenzo[b, e]thiepin-11-one 類とSbCl_5の反応
- Dibenzothiepin誘導体およびその関連化合物 (第3報) Triphenylmethyl Hexachloroantimonate の反応性の研究と6,11-Dihydrodibenzo [b, e]-thiepin-11-ylium Hexachloroantimonate類の合成
- Dibenzothiepin誘導体およびその関連化合物(第1報)11-Phenyl-6,11-dihydrodibenzo[b, e]thiepin-11-ylium Salt類の単離とその新規な脱水素環化反応
- Dibenzothiepin Derivatives and Related Compounds. V. Reactions of 6,11-Dihydrodibenzo [b, e] thiepin 5-Oxides with SbCl_5 and Perchloric Acid
- Dibenzothiepin Derivatives and Related Compounds. II. A Novel Cyclization Reaction of 6-Chloro-11-phenyl-6,11-dihydrodibenzo [b, e] thiepins
- 環状スルホニウムイリド類 : 2-Alkyl(or aryl)-1-benzoyl-1H-2-thianaphthalen-2-ium-1-idesおよび2-Alkyl(or aryl)-1-benzoyl-3,4-dihydro-1H-2-thianaphthalen-2-ium-1-idesの合成と熱反応
- 2-Alkyl(or Aryl)-1-benzoyl-3,4-dihydro-2-thianaphthalenesの合成と熱反応
- Syntheses and Properties of Novel Cyclic Sulfilimines, 2-Azathiabenzene Derivatives
- 新規な環状Sulfilimine類, 2-Azathiabenzene誘導体の合成
- Benzothiazoline Sulfoxide類の非立体特異的環拡大反応
- 5員複素環状スルホキシド類の非立体特異的環拡大反応
- 7員複素環状スルホキシド類, 2,2-ジ置換 1,4-および1,5-Benzothiazepine Sulfoxide類の環変換反応
- Non-stereospecific Ring Expansion Reactions of Benzothiazoline Sulfoxides
- ThiaazulenocycloneとThiazulenocyclone 8,8-Dioxideの合成ならびに環化付加反応
- BenzothiazolineとBenzyneの反応 : 新規複素環硫黄イリド, Benzothiazolinium S-Ylideの発生
- Benzothiazoline Sulfoxide類の非立体特異的環拡大反応
- 1,3-Dipheny -2,8-dihydrodibenzo[e, h]-8-thiaazulen-2-one(Thiaazulenocyclone)の合成とAcetylenes, OlefinsおよびBenzyneとの環化付加反応
- 新環状硫黄イリド, 8-チアアズレン類, 8-Alkyl-1,3-diphenyldibenzo[e, h]-8-thiaazulenesの合成と熱転位反応
- Syntheses and Cycloaddition Reactions of Thiaazulenocyclone and Thiaazulenocyclone 8,8-Dioxide
- Selenoxanthylium Salts. I. Nitration of 9-Phenylselenoxanthylium Perchlorate
- Selenabenzenes. I. Synthesis of 10-Selenaanthracene Derivatives