Studies on Benzothiazoline Derivatives. IV. Synthesis and Novel Ring Expansion Reaction of Benzothiazoline Sulfoxides
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概要
- 論文の詳細を見る
The oxidation of 3-acylbenzothiazolines (IV) with m-chloroperbenzoic acid gave 3-acylbenzothiazoline sulfoxides (V) and sulfone (VI) in high yield. The stereochemistry of the compounds V is discussed on the basis of nuclear magnetic resonance spectroscopic studies. Reaction of the compound V with refluxing acetic anhydride resulted in the formation of novel ring expansion products, 4-acylbenzothiazine derivatives. A mechanism involving the sulfenic anhydride as an intermediate is proposed for this ring expansion.
- 社団法人日本薬学会の論文
- 1979-09-25
著者
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片岡 貞
岐阜薬科大学薬化学講座
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片岡 貞
Gifu Pharmaceutical University
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清水 洋
Gifu Pharmaceutical University
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堀 幹夫
Gifu Pharmaceutical University
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今井 豊
Gifu College of Pharmacy
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