Dibenzothiepin Derivatives and Related Compounds. II. A Novel Cyclization Reaction of 6-Chloro-11-phenyl-6,11-dihydrodibenzo [b, e] thiepins
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概要
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By the reaction of 11-chloro-11-phenyl-(II) and 11-phenyl-6,11-dihydrodibenzo-[b, e] thiepin (III) with NCS 6,11-dichloro-(I) and 6-chloro-11-phenyl-6,11-dihydrodibenzo-[b, e] thiepin (XV) were prepared, respectively. The compound (I) reacted with water or aqueous ammonia to afford a new heterocyclic compound, 6,11-epoxy-(V) or 6,11-epimino-11-phenyl-6,11-dihydrodibenzo [b, e] thiepin (VIII), respectively. On heating in proper solvent, I or XV underwent a novel cyclization to form a bridged compound (IX, XIII or XIV). The radical mechanism for the new cyclization was proposed.
- 公益社団法人日本薬学会の論文
- 1978-07-25
著者
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片岡 貞
Gifu Pharmaceutical University
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清水 洋
Gifu Pharmaceutical University
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堀 幹夫
Gifu Pharmaceutical University
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小野木 和弘
興和研究所
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小野木 和弘
Gifu College of Pharmacy
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