Sulfur-Containing Acylamino Acids. I. Syntheses and Angiotensin I Converting Enzyme-Inhibitory Activities of Sulfur-Containing N-Mercaptoalkanoyl Amino Acids(Medicinal Chemistry,Chemical)
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概要
- 論文の詳細を見る
N-Mercaptoalkanoyl derivatives of sulfur-containing amino acids were synthesized andexamined for inhibitory effects on angiotensin I converting enzyme(ACE) extracted from rabbitlung. Inhibition of ACE was determined by means of a spectrometric assay with hippuryl-L-histidyl-L-leucine as a substrate. Among the synthesized sulfur-containing compounds, N-(2-benzyl-3-mercaptopropanoyl)-S-methyl-L-cysteine(13a) and N(2-benzyl-3-mercaptopropanoyl)-S-ethyl-L-cysteine(13c) showed the most potent inhibitory effects on ACE activity. The IC_<50> values of 13a and 13c on ACE activity were 0.028 and 0.020 μM, respectively.
- 社団法人日本薬学会の論文
- 1987-06-25
著者
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村田 聡
Department Of Pharmacology Osaka University Of Pharmaceutical Sciences
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森本 史郎
Osaka College of Pharmacy
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堀 幹夫
Gifu Pharmaceutical University
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堀 幹夫
岐阜女子大学:岐阜薬科大学
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小森 武勇
Nagoya Research Laboratory, Meito Sangyo Co., Ltd.
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佐々木 康人
Nagoya Research Laboratory, Meito Sangyo Co., Ltd.
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花井 弘美
Nagoya Research Laboratory, Meito Sangyo Co., Ltd.
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浅野 勝美
Nagoya Research Laboratory, Meito Sangyo Co., Ltd.
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瀬尾 瑠美
Osaka University of Pharmaceutical Sciences
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高岡 昌徳
Osaka University of Pharmaceutical Sciences
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森本 史郎
大阪薬科大学
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佐々木 康人
Nagoya Research Laboratory Meito Sangyo Co. Ltd.
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浅野 勝美
Nagoya Research Laboratory Meito Sangyo Co. Ltd.
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小森 武勇
Nagoya Research Laboratory Meito Sangyo Co. Ltd.
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花井 弘美
Nagoya Research Laboratory Meito Sangyo Co. Ltd.
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Murata S
Department Of Pharmacology Osaka University Of Pharmaceutical Sciences
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