Sulfur-Containing Acylamino Acids. II. Syntheses and Angiotensin I Converting Enzyme-Inhibitory Activities of N-Mercaptoal-kanoyl-S-ethyl-L-cysteine(Medicinal Chemistry,Chemical)
スポンサーリンク
概要
- 論文の詳細を見る
N-Mercaptoalkanoyl derivatives of sulfur-containing ammo acids were synthesized as candidate angiotensin I converting enzyme(ACE) inhibitors. Among them, N-[3-mercapto-2-(4-methoxybenzyl)propanoyl]-S-ethyl-L-cysteine(5d) was found to be the most potent inhibitor of ACE, with an 1C_<50> value of 0.045 μ_M. The maximum hypotensive effect of this compound was almost equal to that of captopril in anesthetized rats.
- 社団法人日本薬学会の論文
- 1987-06-25
著者
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森本 史郎
Osaka College of Pharmacy
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堀 幹夫
Gifu Pharmaceutical University
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堀 幹夫
岐阜女子大学:岐阜薬科大学
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小森 武勇
Nagoya Research Laboratory, Meito Sangyo Co., Ltd.
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佐野 勝美
Nagoya Research Laboratory, Meito Sangyo Co., Ltd.
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佐々木 康人
Nagoya Research Laboratory, Meito Sangyo Co., Ltd.
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花井 弘美
Nagoya Research Laboratory, Meito Sangyo Co., Ltd.
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森本 史郎
Osaka University Of Pharmaceutical Sciences
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佐々木 康人
Nagoya Research Laboratory Meito Sangyo Co. Ltd.
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浅野 勝美
Nagoya Research Laboratory Meito Sangyo Co. Ltd.
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小森 武勇
Nagoya Research Laboratory Meito Sangyo Co. Ltd.
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花井 弘美
Nagoya Research Laboratory Meito Sangyo Co. Ltd.
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