Synthesis and Hypoglycemic Activity of 7,8-Dihydro-6H-thiopyrano[3,2-d]pyrimidine Derivatives and Related Compounds
スポンサーリンク
概要
- 論文の詳細を見る
A series of 2-amino-7,8-dihydro-4-piperazinyl- and 4-amino-7,8-dihydro-2-piperazinyl-6H-thiopyrano[3,2-d]pyrimidines and related compounds were synthesized and evaluated for hypoglycemic activity. Several compounds exhibited excellent activity, and 7,8-dihydro-2-(4-methyl-piperazinyl)-4-(1-pyrrolidinyl)- (8c, dimaleate : MTP-1307) and 2-amino-7,8-dihydro-4-piperazinyl-6H-thiopyrano[3,2-d]pyrimidine (18a, dimaleate : MTP-1403) were selected for further investigation.Oral administration of 8c and 18a at 50 mg/kg markedly improved oral glucose tolerance in ob/ob mice. In this test, buformin also showed activity, whereas tolbutamide produced no significant improvement.
- 公益社団法人日本薬学会の論文
- 1986-10-25
著者
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小松 修
Research Laboratories Maruko Seiyaku Co. Ltd.
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加藤 栄一
Research Laboratories Maruko Seiyaku Co. Ltd.
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大野 左千雄
Research Laboratories, Maruko Seiyaku Co., Ltd.,
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水越 清史
Research Laboratories, Maruko Seiyaku Co., Ltd.,
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久納 保夫
Research Laboratories, Maruko Seiyaku Co., Ltd.,
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中村 芳樹
Research Laboratories, Maruko Seiyaku Co., Ltd.,
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長坂 光昭
Research Laboratories, Maruko Seiyaku Co., Ltd.,
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水越 清史
Research Laboratories Maruko Seiyaku Co. Ltd.
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長坂 光昭
Research Laboratories Maruko Seiyaku Co. Ltd.
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中村 芳樹
Research Laboratories Maruko Seiyaku Co. Ltd.
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大野 左千雄
Research Laboratories Maruko Seiyaku Co. Ltd.
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大野 佐千雄
Research Laboratories Maruko Pharmaceutical Co. Ltd.
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久納 保夫
Research Laboratories Maruko Seiyaku Co. Ltd.
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