S-Adenosylmethionine (SAM)-Accumulating Sake Yeast Suppresses Acute Alcohol-Induced Liver Injury in Mice
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概要
- 論文の詳細を見る
The suppressive effects on acute alcoholic liver injury of S-adenosylmethionine (SAM) and the sake yeast, Saccharomyces cerevisiae Kyokai No. 9, have been shown previously. To enhance the suppression of acute alcoholic liver injury by sake yeast, we prepared SAM-accumulating sake yeast (SAM yeast). Male C57BL/6 mice that had been fed on a diet containing 0.25% SAM yeast or sake yeast for two weeks received three doses of ethanol (5 g/kg BW). In the mice fed on the SAM yeast, the ethanol-induced increases in both triglyceride (TG) and alanine aminotransferase (ALT) were significantly repressed. In addition, the SAM yeast-fed mice did not show an ethanol-induced decrease in hepatic SAM level, suggesting that a disorder of methionine metabolism in the liver caused by ethanol was relieved by the SAM yeast. These results suggest that the SAM yeast had a stronger effect suppressing acute alcoholic liver injury in mice than the sake yeast.
- 社団法人 日本農芸化学会の論文
- 2006-12-23
著者
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Iefuji Haruyuki
National Research Institute of Brewing
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Iefuji Haruyuki
Graduate School of Biosphere Science, Hiroshima University
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Iefuji Haruyuki
National Res. Inst. Of Brewing
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Iefuji Haruyuki
National Research Institute Of Brewing:graduate School Of Biosphere Sciences Hiroshima University
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Shobayashi Megumi
National Research Institute of Brewing
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IZU Hanae
National Research Institute of Brewing
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MANABE Yasuko
National Research Institute of Brewing
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GOTO Kuniyasu
National Research Institute of Brewing
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Izu Hanae
National Res. Inst. Of Brewing
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Goto Kuniyasu
National Res. Inst. Of Brewing
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