Protective Effects of a Novel Quinone Derivative, E3330, on Mouse Hepatitis Virus (MHV)-Induced Chronic Hepatitis in Athymic Nude Mice
スポンサーリンク
概要
- 論文の詳細を見る
In this experiment, we examined the protective effects of a novel quinone derivative, E3330, on MHV-2cc-induced chronic hepatitis in athymic nude mice for up to 3 weeks after virus infection. The daily dose of 25 mg/kg b.w. suppressed the viral replication in the liver and the progression of hepatic lesions. The expansion of small focal lesions at 1 week after viral inoculation (WAI) was suppressed at 2 WAI, and the lesions were still small at 3 WAI in E3330-administered group, whereas small focal lesions at 1 WAI were expanded at 2 WAI to fuse with each other at 3 WAI in the control group. E3330 therefore showed protective effects on MHV-2cc-induced chronic hepatitis in athymic nude mice, but further studies are needed to analyze the mechanism.
- 社団法人 日本実験動物学会の論文
著者
-
Uetsuka Koji
Department Of Veterinary Pathology Faculty Of Agriculture The University Of Tokyo
-
Uetsuka Koji
Department Of Veterinary Pathology The University Of Tokyo
-
GOTO Naoki
Shin Nippon Biomedical Laboratories, Ltd.
-
KAI Chieko
Department of Veterinary Microbiology, Faculty of Agriculture, the University of Tokyo
-
Kai Chieko
Department Of Veterinary Microbiology Faculty Of Agriculture The University Of Tokyo
-
Kai C
Department Of Veterinary Microbiology Faculty Of Agriculture The University Of Tokyo
-
Suzuki Michio
Department Of Electronics Faculty Of Engineering Hokkaido University
-
Goto Naoki
Shin Nippon Biomedical Laboratories Ltd. Tokyo Byouri Center
-
Goto Naoki
Shin Nippon Biomedical Laboratories Ltd.
-
Suzuki Michio
Department Of Agricultural Chemistry Faculty Of Agriculture Tohoku University
-
Suzuki Michio
Department Of Veterinary Pathology The University Of Tokyo
関連論文
- Involvement of Sex, Strain and Age Factors in High Fat Diet-Induced Obesity in C57BL/6J and BALB/cA Mice
- Depressive effects of immunosuppressant and anti-inflammatory drugs on HgCl_2-induced inflammatory lesions in Brown Norway rat(Immune system, Allergy, Proceedings of the 32nd Annual Meeting)
- MMP/TIMP activities in DMBA-induced rat mammary gland tumors(Mutagenicity, Carcinogenicity, Proceedings of the 32nd Annual Meeting)
- Induction of Cytochrome P450 isozymes by phenobarbital in pregnant rat and fetal livers and placenta(Drug metabolism, Proceedings of the 32nd Annual Meeting)
- Histopathological changes in the brain of mouse fetuses by etoposide-administration(Proceedings of the 32nd Annual Meeting)
- 1-β-D-Arabinofuranosylcytosine (Ara-C)-induced Apoptosis in the Rat Fetal Tissues and Placenta
- Gene Expression Profiles in the Liver, Placenta and Fetal Liver in Pregnant Rats Treated with T-2 Toxin (TOXICOGENOMICS AND TOXICOPROTEOMICS) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30th Annual Meeting)
- DNA Damages and Changes in Proliferating Activity in the Dorsal Epidermis of UVB-Irradiated WBN/ILA-Ht Rats
- T-2 Toxin-Induced Morphological Changes in Pregnant Rats
- Effects of Exogenous Growth Hormone (GH)-Treatment on Carbon Tetrachloride (CCl_4)-Induced Acute Liver Injury in GH-Deficient Mini Rats
- Effects of T-2 Toxin on the Expression of Connexin 32 in the Mouse Liver
- Effects of T-2 Toxin Treatment on CCl_4-Induced Hepatic Necrosis in Mice
- Liver Responses to Repeated Doses of Carbon Tetrachloride in Mini and Wistar Rats
- Teratologic Studies on Rat Perinates and Offspring from Dams Treated with Ethylnitrosourea (ENU)
- Tissue Distribution and Sequence of T-2 Toxin Induced-Apoptosis
- Changes in Location and Number of Tartrate-Resistant Acid Phosphatase (TRAP)-Positive Cells During the Development of Type II Collagen-Induced Arthritis in DBA/1J Mice
- Immunohistochemical Study on Type II Collagen-Induced Arthritis in DBA/1J Mice
- Immunohistochemical Study on Galactosamine-Induced Subacute Hepatitis in Rats of JCL: Wistar-TGN (ARGHGEN) 1Nts Strain (Mini rats)
- Age-Related Changes in Susceptibility of Mice to Low-Virulent Mouse Hepatitis Virus (MHV-2-CC) Infection
- Changes in limbic dopamine metabolism following quinolinic acid lesions of the left entorhinal cortex in rats
- Widespread expression of Fos protein induced by acute haloperidol administration in the rat brain
- Finite-Element Analysis of Discontinuities in an Elastic Plate Waveguide for Lamb Waves and its Applications : Surface Acoustic Waves and Devices
- Finite-Element Analysis of Acoustic Surface Waveguides Using Approximate Analytical Solutions : Fundamentals
- Application of Finite Element Method to Acoustic Guidedwave Problems : Physical Acoustics I
- New Isolates of Pneumonia Virus of Mice (PVM) from Japanese Rat Colonies and their Characterization
- Equivalent Circuit Model for Positive/Negative Reflection-Type SAW Reflectors : SAW and BAW Materials, Devices and Theories
- Equivalent Networks for Surface Acoustic Wave Metallic Gratings : SAW and Communication Devices
- Finite-Element Analysis of Periodic Waveguides for Acoustic Waves : SAW and Communication Devices
- Hypereosinophilic Syndrome in Two Cats(Clinical Pathology)
- Isolation and characterization of an additional crustacean hyperglycemic hormone from the greasyback shrimp Metapenaeus ensis
- T-2 Toxin Induced Skin Lesions in Hipotrichosis (Ht) Rats
- 5-Azacytidine-induced Apoptosis in the Central Nervous System of Developing Rat Fetuses
- Process of the Development of T-2 Toxin-induced Apoptosis in the Lymphoid Organs of Mice
- Community-acquired Acinetobacter baumannii meningitis in a previously healthy 14-month-old boy
- Glycoconjugate Expression in Follicle-Associated Epithelium (FAE) Covering the Nasal-Associated Lymphoid Tissue (NALT) in Specific Pathogen-Free and Conventional Rats
- Renal Tubulointerstitial Lesions in Mercuric Chloride-Treated Brown Norway Rats
- Lectinhistochemistry of Dorsal Skin of Wistar-derived Hypotrichotic WBN/Ila-Ht Rats
- STUDIES ON PRISMALIN-14, A NOVEL MATRIX PROTEIN FROM THE PRISMATIC LAYER OF JAPANESE PEARL OYSTER, PINCTADA FUCATA(Cell Biology and Morphology,Abstracts of papers presented at the 75^ Annual Meeting of the Zoological Society of Japan)
- Hepatitogenicity of Three Plaque Purified Variants of Hepatotropic Mouse Hepatitis Virus, MHV-2 in Athymic Nude Mice
- Protective Effect of Recombinant Interferon (IFN) α/β on MHV-2cc-induced Chronic Hepatitis in Athymic Nude Mice
- Finite-Element Analysis of Finite Periodic Waveguides for Surface Acoustic Waves : SAW and Communication Devices
- Five-day oral cefditoren pivoxil versus 10-day oral amoxicillin for pediatric group A streptococcal pharyngotonsillitis
- Disseminated Histiocytic Sarcoma with Excessive Hemophagocytosis in a Cat
- STUDIES ON A MATRIX PROTEIN IN THE PRISMATIC LAYER OF JAPANESE PEARL OYSTER, PINCTADA FUCATA(Cell Biology and Morphology)(Proceedings of the Seventy-Third Annual Meeting of the Zoological Society of Japan)
- Proton magnetic resonance spectroscopy of the inferior frontal gyrus and thalamus and its relationship to verbal learning task performance in patients with schizophrenia : A preliminary report
- Sylvian fissure and medial temporal lobe structures in patients with schizophrenia : A magnetic resonance imaging study
- Development of Restriction Fragment-Length Polymorphism Method to Differentiate Five Subtypes of Feline Immunodeficiency Virus
- Detection of Streptobacillus spp. in feral rats by specific polymerase chain reaction
- Identification of Chitin in the Prismatic Layer of the Shell and a Chitin Synthase Gene from the Japanese Pearl Oyster, Pinctada fucata
- Incorporation of β-amyloid protein through the bovine ileal epithelium before and after weaning : Model for orally transmitted amyloidoses
- Structural Determination and Functional Analysis of a Soluble Matrix Protein Associated with Calcification of the : Exoskeleton of the Crayfish, Procambarus clarkii
- Protective Effects of a Novel Quinone Derivative, E3330, on Mouse Hepatitis Virus (MHV)-Induced Chronic Hepatitis in Athymic Nude Mice
- RELATION BETWEEN RESPIRATION AND TRANSLOCATION OF PHOTOSYNTHETIC PRODUCTS
- EFFECTS OF TEMPERATURE AND LIGHT ON THE TRANSLOCATION OF PHOTOSYNTHETIC PRODUCTS
- STUDIES ON THE CARBON METABOLISM IN THE HIGHER PLANT I. ON THE NEWLY DEVICED APPARATUS FOR THE MEASUREMENT OF THE PHOTOSYNTHESIS
- Association study of ubiquitin-specific peptidase 46 (USP46) with bipolar disorder and schizophrenia in a Japanese population
- A two-stage case-control association study of the dihydropyrimidinase-like 2 gene (DPYSL2) with schizophrenia in Japanese subjects
- Picryl Chloride-Induced Contact Dermatitis in IQI/Jic Male Mice
- Effects of Granulocyte Colony-Stimulating Factor on the Development of Inflammation in Bleomycin-Induced Lung Injury
- Development of Apoptosis and Changes in Apoptosis-Related Genes Expression in the Thymus of Nivalenol-Treated Mice
- Early Ultrastructural Changes in the Dorsal Skin Epidermis of Wistar-Derived Hypotrichotic WBN/ILA-Ht Rats after UVB-Irradiation
- STUDIES ON THE CARBON METABOLISM IN THE HIGHER PLANTS II. STRUCTURAL DISTRIBUTION OF THE CARBON-14 ABSORBED THROUGH THE LEAF IN THE RICE PLANT
- Expression of the Nucleocapsid Protein Gene of the Canine Distemper Virus.
- Intracranial Meningioma with Polygonal Granular Cell Appearance in a Chihuahua
- Immunohistochemical Study on Hepatic Component Cells and Extracellular Matrix in Wistar Rats with Galactosamine-induced Acute Hepatitis.
- Histopathological Characteristics of Ito Cells and Kupffer Cells in the Feline Liver
- Identification and DNA Sequence Analysis of the Marek's Disease Virus Serotype 2 Gene Homologous to the Herpes Simplex Virus Type 1 Glycoprotein H.
- Histopathological Characteristics of Kupffer Cells and Ito Cells in the Porcine and Bovine Liver
- Structural and Functional Analyses of a Strong Chitin-Binding Protein-1 (SCBP-1) from the Exoskeleton of the Crayfish Procambarus clarkii