The template-directed synthesis of oligonucleotide. II. The interactive properties of nucleic adid base-binding poly(4-vinylpyridine) and its related compound with nucleotides.
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概要
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The interactive properties of positively charged polynucleotide analogs, such as nucleic acid base-binding poly(4-vinylpyridine)s and their derivatives, with nucleotides have been investigated. The interactions of the positively charged polynucleotide analogs such as <I>N</I>-alkylated poly(4-vinylpyridine)s with 9-(ω-chloroalkyl)adenine and of <I>N</I>-alkylated poly(4-vinylpyridine) with 1-(2-bromoethyl)thymine with nucleotides were attributed predominantly to a base-base stacking under reinforcement by the coulombic attractive force. The purinepurine base interaction was found to be stronger than the purine-pyrimidine and the pyrimidine-pyrimidine interactions. The interaction was reduced by an increase in the ionic strength. The higher the charge density of the nucleotide was, the stronger was the interaction observed. On the other hand, a cross-linked positively charged polynucleotide analog such as <I>N</I>-alkylated cross-linked poly(4-vinylpyridine) with 9-(2-chloroethyl)adenine showed considerable selective interaction with the complementary nucleotide, uridine-5′-phosphate (pU), in both aqueous and pyridine solutions.
- 公益社団法人 日本化学会の論文
著者
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Minami Manabu
Department Of Cardiovascular Medicine Graduate School Of Medicine Kyoto University
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Konishi Yoshiyuki
Department Of Biology Faculty Of Science Chiba University
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SHIMIDZU Takeo
Department of Molecular Engineering, Graduate School of Engineering, Kyoto University
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Murakami Akira
Department Of Biomolecular Engineering Graduate School Of Science And Technology Kyoto Institute Of
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Murakami Akira
Department of Hydrocarbon Chemistry, Faculty of Engineering, Kyoto University
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