Studies on 2-aziridinecarboxylic acid. II. A novel synthesis of threonine O-peptide derivatives via (2S,3S)-3-methyl-2-aziridinecarboxylic acid.

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概要

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• A new synthesis of threonine <I>O</I>-peptides <I>via</I> the ring opening reaction of aziridine peptide with carboxylic acid has been investigated. Benzyl (2<I>S</I>,3<I>S</I>)-1-[<I>N</I>-(benzyloxycarbonyl)glycyl]-3-methyl-2-aziridinecarbonylglycinate was treated with several <I>N</I>-protected amino acids or dipeptides at their mixed melting point, and the corresponding <I>O</I>-aminoacyl or dipeptidyl esters of L-threonine peptide derivative were obtained in good yields without racemization.

• 公益社団法人 日本化学会の論文

著者

• Nakamura Akihiro

  Department Of Applied Chemistry And Biotechnology Faculty Of Engineering Yamanashi University

• MAEDA Toru

  Department of Hospital Pharmacy, Nagoya City University Hospital

• Tanaka Takumi

  Department of Chemistry, Faculty of Science, Kwansei Gakuin University

• Nakajima Kiichiro

  Department of Chemistry, Faculty of Science, Kwansei Gakuin University

• Okawa Kenji

  Department of Chemistry, Faculty of Science, Kwansei Gakuin University

• Hayashi Noboru

  Department of Chemistry, Faculty of Science, Kwansei Gakuin University

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