Studies on 2-aziridinecarboxylic acid. IV. Total synthesis of actinomycin D (C1) via ring-opening reaction of aziridine.
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概要
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Actinomycin D (C<SUB>1</SUB>) has been synthesized by a route involving the ester formation between two peptide fragments, (2<I>S</I>,3<I>S</I>)-1-(2-nitro-3-benzyloxy-4-methylbenzoyl)-3-methyl-2-aziridinecarbonyl-D-valylproline <I>t</I>-butyl ester and <I>N</I>-benzyloxycarbonylsarcosyl-<I>N</I>-methylvaline, <I>via</I> a ring-opening reaction of aziridine. Cyclization, followed by reduction and oxidation, gave actinomycin D (C<SUB>1</SUB>). The synthetic actinomycin D (C<SUB>1</SUB>) was indistinguishable from natural substance as regards physical properties and biological activity.
- 公益社団法人 日本化学会の論文
著者
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Tanaka Takumi
Department of Chemistry, Faculty of Science, Kwansei Gakuin University
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Nakajima Kiichiro
Department of Chemistry, Faculty of Science, Kwansei Gakuin University
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Okawa Kenji
Department of Chemistry, Faculty of Science, Kwansei Gakuin University
関連論文
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