Studies on 2-aziridinecarboxylic acid. VIII. Total synthesis of actinomycin D and its serine analogue via ring-opening reaction of 1-benzyloxycarbonyl-2-aziridinecarboxylic acid moiety.
スポンサーリンク
概要
- 論文の詳細を見る
Direct synthesis of peptides containing 1-benzyloxycarbonyl-2-aziridinecarboxylic acid were carried out by the reaction of β-hydroxy-α-amino acid peptides with DEAD–TPP reagents, and key <I>O</I>-peptide intermediates of actinomycin D synthesis were prepared <I>via</I> a ring-opening reaction of the aziridine with <I>N</I>-protected dipeptide. Peptide lactone was prepared by the DCC–HOBt method, and the subsequent debenzyl procedure and oxydation procedure gave the title compounds in good yields.
- 公益社団法人 日本化学会の論文
著者
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Tanaka Takumi
Department of Chemistry, Faculty of Science, Kwansei Gakuin University
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Nakajima Kiichiro
Department of Chemistry, Faculty of Science, Kwansei Gakuin University
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Neya Masahiro
Department of Chemistry, Faculty of Science, Kwansei Gakuin University
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Okawa Kenji
Department of Chemistry, Faculty of Science, Kwansei Gakuin University
関連論文
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