骨髄に多数のringed sideroblastを認めた赤白血病の1症例

概要

論文の詳細を見る
In March 1976, a 63 year old male was admitted to our hospital due to fever and heart palpitations. Laboratory tests revealed severe hypochromic anemia, leukocytosis and thrombocytopenia. Juvenile granulocytes in various stages and nucleated red blood cells were observed in the peripheral blood. The number of nucleated cells increased and the megaloblastoid cell level in the bone marrow was found to be 2 %. Sideroblasts were increased and 75 % of them were of the ringed-type. Serum iron level was elevated and the utilization of iron in the red blood cells was impaired. These findings showed both characteristics of sideroblastic anemia and erythroleukemia. The patient died due to gastrointestinal hemorrhage in June 1976. It is well known that in some cases acute myelogenous leukemia is the sequel to primary-acquired sideroblastic anemia. Dameshek reported that the first stage of erythroleukemia was often identical to refractory sideroblastic anemia. This case is assumed to be an internal-type of erythroleukemia and refactory sideroblastic anemia.
学校法人昭和大学・昭和医学会の論文