ヘパリンによる出血凝固系諸検査成績の改善をみた前骨髄球性白血病の1例

概要

論文の詳細を見る
A 24-year-old woman was admitted to the hospital because of hematuria, headache and lethargy as chief complaint. Laboratory examination revealed anemia, marked increase of leucocyte, and decrease of blood platelet. Leucocyte analysis proved that both myeloblast and promyelocyte occupied 98%. These cells were also observed in the spinal fluid. A diagnosis was promyelocytic leukemia accompanied with disseminated intravascular coagulation and subarachnoid infiltration, substantiated by the abnormal hemostasis, the increase of FDP and the extraordinary reduction of euglobulin lysis time.<BR>Anti-leukemic agent and heparin were concomitantly given and the abnormal hemostasis was temporarily improved. However the patient later died of cardiac insufficiency. Autopsy findings did not reveal any microthrombus. In this experience, the discussion was made on the correlation between promyelocytic leukemia and disseminated intravascular coagulation on the significance of heparin administration.