慢性肝疾患および慢性骨髄増殖性疾患における血清鉄,フェリチン,セルロプラスミンの意義

概要

論文の詳細を見る
Clinical significances of serum iron, ferritin and ceruloplasmin were studied in patients with chronic liver diseases and chronic myeloproliferative disorders, and results follow: In liver cirrhosis, serum iron concentrations and total iron-binding capacity were normal or decreased, otherwise, serum f erritin levels were increased. These findings might suggest the disturbance of iron utilization. There was a positive correlation between serum iron concentrations and serum f erritin levels, and a negative correlation between total ironbinding capacity and serum ferritin levels. A significant correlation was seen between serum ceruloplasmin levels and serum iron concentrations. In polycythemia vera, serum iron concentrations were within normal ranges and serum ferritin concentrations were low, which suggested latent iron deficiency accompanied by erythroid hyperplasia. Hyperf erritinaemia and hyperceruloplasminaemia were found in patients with chronic myeloid leukemia, primary myelofibrosis and idiopathic thrombocythemia, which seemed to be manifestations involved in a bone marrow prolif erative process. Serum ferritin levels were closely correlated with serum LDH in chronic myeloid leukemia.
学校法人昭和大学・昭和医学会の論文