各種疾患におけるCeruloplasminとApo-ceruloplasmin
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In this study, the oxidized form of plasma ceruloplasmin, which has been know to act as ferroxidase in vivo, was oxidized up to 90% ; small amounts of apoceruloplasmin (10-20%) were contained in normal plasma. At present, estimation of apoceruloplasmin alone is difficult, but the immunological method allows the simultaneous measurement of apocer-uloplasmin and the oxidated-type of ceruloplasmin. The plasma content of oxidized ceruloplasmin is determined by the measurement of paraphenylenediamine oxidase activity ; it is therefore possible to measure the apoceruloplasmin concentration indirectly. In the present study, we measured serum ceruloplasmin by the oxidase activity and the immunological method for 38 control cases, 17 cases of liver cirrhosis, 15 cases of acute hepatitis, 7 cases of chronic hepatitis, 33 cases of iron deficient anemia, 12 cases of aplastic anemia, 13 cases of leukemia, 23 cases of cancer, 13 cases of acute nephritis, 6 cases of chronic nephritis, 4 cases of nephrotic syndrome, 11 cases undergoing blood dialysis treatment and 10 pregnancies. The concentrations of apoceruloplasmin and oxidized ceruloplasmin varied with the type and severity of the disease. Comparison of the values measured with oxidase activity and by the immunological method revealed that, in some cases, the biosynthesis of apoceruloplasmin was suppressed and, in other cases, the binding of apoceruloplasmin to copper was impaired.
- 学校法人 昭和大学・昭和医学会の論文
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