Mycobacterium auium-Mycobacterium intracellulareによる肺感染症に対するMinocyclineを含む化学療法の臨床効果

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Clinical effect of chemotherapy including minocycline on lung infection due to Mycobacterium avium-Mycobacterium intracellulare complex was studied in the present study, based on a previous observation by Tsukamura who showed in vitro effectiveness of minocycline on this organism. The Minocycline group consisted of 12 patients (8 male and 4 female) with average age of 63.6±11.1 years, and the control group of 33 patients (23 male and 10 female) with average age of 57.9±13.4. The patients had body weight 43.5 kg in average (32 to 51 kg). They showed at least three times excretion of the organism into sputum before and showed two or more excretions of the organism in three months immediately before the beginning of the study. Furthermore, at least one or more excretions showed more than 100 colonies. The minocycline group received chemotherapy with three agents, minocycline (100mg per os daily), enviomycin (1g per day, intramuscular, three times weekly), and rifampicin (0.45 g per os daily) (8 patients) or the above three plus ethambutol (0.75g per os daily) (4 patients). The control group received administration of three agents among the following: Streptomycin; kanamycin; capreomycin; isoniazid; p-aminosalicylate; rifampicin; ethambutol; pyrazinamide; ethionamide; cycloserine. The control group was obtained retrospectively from patients of the National Chubu Hospital, who were hospitalized in the past three years. Both groups were observed for six months and followed up by monthly sputum examinations. The results are shown in Fig. 1 and Table 1. Negative conversion was obtained in the minocycline group at a rate of 75% (9/12), and in the control group at a rate of 36% (12/33). No side-effect of minocycline was observed throughout the study. From the above finding, it has been considered that chemotherapy including minocycline (minocycline plus enviomycin plus rifampicin, or minocycline plus enviomycin plus rifampicin plus ethambutol) is considerably effective for lung infection due to M. intracellulare.
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<I>Mycobacterium auium-Mycobacterium intracellulare</I>による肺感染症に対するMinocyclineを含む化学療法の臨床効果

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