Analysis of the cell cycle using a monoclonal antibody against PCNA, and its significance in the squamous cell carcinoma of the oral cavity.

概要

論文の詳細を見る
The proliferative capacity of the oral squamous cell carcinoma (SCC) was analyzed immunohistochemically using monoclonal antibody against proliferating cell nuclear antigen (PCNA.) The PCNA-positive cell was detected in all cases of formalin fixed, paraffin embedded specimen from SCC and normal epithelium. The percentage of the PCNA-positive cells in SCC ranged from 0.8% to 23. 3%, and its mean value ± S. E. was 11.2±0.98%(n=36). In oral SCC, PCNA-positive rate correlated with the differentiation and cellular atypism of SCC, while there was'nt a significant difference in the relationship with the stage of the disease and the patient's prognosis. These findings suggest that immunostaining of PCNA is a convenient and important new method by which to estimate the cellular proliferation rate of oral cancer.
社団法人日本口腔外科学会の論文