悪性唾液腺腫瘍におけるp53蛋白の免疫組織化学的発現と病理組織学的因子との関連性について

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This study was designed to investigate the relationship between immunohistochemical detection of p53 protein and pathological features in 101 cases of malignant salivary gland tumors (SGT). Immunoreactivity of p53 protein was observed in 24 of 101 (23.8%) cases of malignant SGT. The frequency of p53 immunoreactivity in various types of malignant SGT were: adenoid cystic carcinoma: 5/27 (18.5%); acinic cell carcinoma: 7/13 (53.8%); carcinoma in pleomorphic adenoma: 7/21 (33.3%); other types of adenocarcinoma including 3 cases of undifferential carcinoma: 5/15 (33.3%); mucoepidermoid carcinoma: 0/25. These data suggested that the expression of p53 protein was commonly involved in malignant SGT and that the p53 positive rate was different among various histological types of malignant SGT.
社団法人日本口腔外科学会の論文