口底に発現した明細胞腺腫の1例

概要

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Cells with a transparent cytoplasm are often seen in organs such as the kidney and adrenal glands, and often appear in salivary gland tumor cells such as mucoepidermoid or acinic cell tumors. However, clear cell adenoma of salivary glands is very rare.<BR>A 53-year-old male demonstrated a mass in the left oral floor and was treated by surgical resection. It was not strongly adherent to the surrounding tissue. Histo-pathologically the tumor tissue was found to be exclusively composed of clear cells arranged focally and linearly. The clear cells in this case were of a nonmucoid type which may or may not contain glycogen. I mmunohistochemical staining was negative for CEA, S-100 protein and SCC antibody. The average number of Ag-NORs were 1.47 suggesting a low grade of malignancy. Morphologically speaking, clear cell adenoma can be divided into two variants: bimorphic and monomorphic. The case in study was of the monomorphic type.<BR>Follow up was performed for 2 and half years no evidence of metastasis or local recurrence was noted during that time.