T cell subsets in the peripheral blood and the liver tissue of patients with eAg positive and eAb positive chronic active hepatitis.

概要

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The T cell subsets in the peripheral blood and the portal area of liver biopsy specimens of patients with eAg positive and eAb positive chronic active hepatitis were investigated using OKT and Leu series. In eAb positive chronic active hepatitis, OKT3 and OKT8 positive cells in the peripheral blood were decreased as compared with those of eAg positive chronic active hepatitis and control. Leu 2a positive cells in the portal area of liver biopsy specimens of patients with eAb positive chronic active hepatitis were decreased as compared with those of eAg positive chronic acitve hepatitis. Therefore, it possibly seems that the decrease of suppressor T cell plays an important role in the seroconversion from eAg to eAb. On the other hand, Leu2a positive cells in the area with piecemeal necrosis of patients with eAb positive chronic active hepatitis were few as compared with those of eAg positive chronic active hepatitis. From these findings, it might be possible that the suppressor T cell system may be related to the reduction of killer T cell in liver tissue.
財団法人日本消化器病学会の論文