DIAGNOSTIC USEFULNESS OF GLYCYLPROLINE-DIPEPTIDYL- AMINOPEPTIDASE ACTIVITIES IN SERA OF PATIENTS WITH VARIOUS HEPATOBILIARY DISEASES

概要

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Diagnostic usefulness of serum GPDA activities in patients with various hepatobiliary diseases was evaluted, in comparison with other hepatobiliary enzymes which had been commonly used for liver function tests. Serum GPDA activities were significantly increased in various hepatobiliary diseases. The incidence of abnormality was remarkable in acute liver injury such as acute hepatitis and acute alcoholic hepatitis, and intrahepatic cholestasis such as primary biliary cirrhosis and a cholestatic type of drug induced liver injury. In paticular, the patients whose serum activities having remarkably increased GPDA were most frequently observed in cases of intrahepatic cholestasis. In view of the abnormal incidence of serum GPDA activities, the sensitivity of this enzyme wes lower than those of γ-GTP, GOT and GPT, but was the same as that of ALP, and higher than that of LDH. GPDA had the most significant correlation with γ-GTP among all other hepatobiliary enzymes.From these results, the measurement of GPDA in serum can be used as an useful examination in the diagnosis of hepatobiliary diseases.