Nine cases of acute hepatic failure on chronic liver disease.

概要

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We clinicopathologically evaluated the difference between acute hepatic failure and acute hepatic failure on chronic liver disease. We had 50 cases with signs of acute hepatic failure for during a period of 24 years. 41 of the 50 cases had acute hepatic failure (acute group) and 9 of them had acute hepatic failure on chronic liver disease (acute on chronic group). According to the initial signs and symptoms, in only acute group, fever and encephalopathy were found in 9.8% and 7.3% of them respectively. The cases which showed encephalopathy within 10 days after onset and the cases which died within one month after onset amounted to 31.7% of the acute group, but not in the acute on chronic group. All of the acute on chronic group died, but 12.2% of the acute group were still alive. The weights of the liver and spleen in both groups were not so different, The histological findings of the liver in both groups showed submassive necrosis.<BR>From the above, it appeared that there was clinicopathologically no difference between two groups, except that the clinical course of the acute on chronic group was aubacute and its prognosis was very poor.
社団法人日本肝臓学会の論文