:The Usefulness of Polyacrylamide Slab Gel Electrophoresis

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We studied the isozymes of serum cholinesterase (herein after referred to as ChE) in 15 normal subjects and 187 patients with liver diseases by polyacrylamide slab gel electrophoresis. The polyacrylamide slab gel electrophoresis was very useful for the separation of ChE isozymes and bands 5 and over were clearly distinguished by this method. In acute hepatitis, ChE activities of each band decreased at the acute phase and recovered to the normal level at the convalescent phase. In fatty liver, ChE activities of each band increased before diet therapy and recovered to the normal level after diet therapy. As liver disease progressed, ChE activities of Band 1 (the fast moving band) to 4 tended to decrease as compared with Band 5 and over. Especially in liver cirrhosis, those decreases were marked. We concluded that this result could not be solely due to the decrease in total ChE activity.
財団法人日本消化器病学会の論文