Measurement of prothrombin-related antigen, des-gamma-carboxy prothrombin and vitamin K in human liver tissues.

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The amounts of prothrombin-related antigen, des-gamma-carboxy prothrombin and vitamin K concentration were determined in human liver tissues. Both prothrombin-related antigen and desgamma-carboxy prothrombin contents were significantly increased in hepatoma tissues as compared with non-cancerous liver tissues. Tissue des-gamma-carboxy prothrombin content was well correlatedwith plasma levels in patients with hepatocellular carcinoma, suggesting a tumor production of desgamma-carboxy prothrombin. Between the amount of prothrombin-related antigen, however, did not correlated neither with tissue nor plasma levels of des-gamma-carboxy prothrombin. Prothrombin synthesized in hu-H1 cells eliminated rapidly, which was demonstrated by pulselabeling using 35Smethionine, suggesting that hepatoma cells have no defect in its ability to excrete prothrombin. So it was indicated that over-production of prothrombin (prothrombin precursor) may play some role in the synthesis of des-gamma-carboxy prothrombin. Vitamin K (K1, MK-4, MK-7) concentration revealed no significant difference between in cancerous and non-cancerous portion of the liver, indicating that the significant difference between in cancerous and non-cancerous portion of the liver, indicating that the possible vitamin K deficiency is not essential.
社団法人日本肝臓学会の論文