Influence of Salicylazosulphapyridine on Human Peripheral Blood Lymphocytes

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Influence of salicylazosulphapyridine, a medicine for inflammatory bowel disease, on peripheral blood lymphocytes in healthy subjects was examined by chromium release assay.The following results were obtained.1. Inhibition by salicylazosulphapyridine on the PHA-induced cytotoxic action of human lymphocytes was obserbed by using mouse L cells as target cell.2. The degree of inhibition for cytotoxicity was inversely proportionate to the viability of the lymphocytes.3. Lymphocytes pretreated with salicylazosulphapyridine synthesized about similar amounts of DNA by PHA stimulation in comparison with DNA synthesis by untreated lymphocytes.4. The toxic action of salicylazosulphapyridine was examined by using human lymphocytes, human erythrocytes, human Chang liver cells and mouse L cells as targets.As a result, lymphocytes were more sensitive than other cells to the toxic action of salicylazosulphapyridine, indicating that salicylazosulphapyridine has selectively the toxic action for the lymphocytes.The above results suggest that salicylazosulphapyridine has some inhibitory action for immune system in vivo.
財団法人日本消化器病学会の論文