IMMUNOLOGICAL STUDY ON ULCERATIVE COLITIS:Lymphocyte-mediated Cytotoxicity by Colonic Mucosal and Enterobacterial Antigens

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Colonic mucosal and enterobacterial antigen-induced cytotoxicity of lymphocytes in patients with ulcerative colitis on non-specific target L cells was studied using 51Cr release assay. PHA-induced cytotoxic effect of lymphocytes was also studied. The following results were obtained.1. There was no statistically significant difference between PHA-induced cytotoxicity of lymphocytes from patients with ulcerative colitis and from healthy controls on L cells.2. The cytotoxic effect of lymphocytes from patients with ulcerative colitis on L cells was obviously low in quiscent stage compared with that in other stages.3. The lymphocyte-mediated cytotoxicity by colonic mucosal and enterobacterial antigens was respectively found in 13% and 29% of patients with ulcerative colitis which was clinically diagnosed as active stage.4. In healthy controls, significant cytotoxicity of lymphocytes to both antigen was not detected.
財団法人日本消化器病学会の論文