ON THE ACTIVITY TO INDUCE AND ADTIVATE DELAYED HYPERSENSITIVITY OF ENTEROBACTERIAL COMMON ANTIGEN AND BACTERIAL LIPOPOLYSACCHARIDE

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While in a few cases of ulcerative colitis, titers of anti-enterobacterial common antigen antibody were high, there were high titers in many cases of liver diseases, such as liver cirrhosis and fluminant hepatitis.Both enterobacterial common antigen and bacterial lipopolysaccharide had activity to induce delayed hypersensitivity against protein antigen in guinea pig, respectively. The activity of lipopolysaccharide was influenced by either its own structure or age of animal, that is, while wild type of lipopolysaccharide showed its activity in relatively matured animal, inability of activation and induction of delayed hypersensitivity was shown in inmatured animal. Re type of lipopolysaccharide, e.g. lipid A+KDO, however, had its activity in younger animal.
財団法人日本消化器病学会の論文