I. Clinical Effect of Topically Administered Salicylazosulphapyridine on Ulcerative Colitis:The Meanings of the Combination of Oral and Topical Therapy

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Suppositories of salicylazosulphapyridine (SASP) were administered for the treatment of ulcerative colitis. In 24 cases (75%) out of 32 patients with this disease, improvements were observed in clinical signs and/or endoscopic findings. In 14 patients of these 32 cases, suppositories were only administered, and good effect of this local therapy for this illness was recognized in 7 cases (50 %). In remaining 18 patients, both topical and oral administrations were carried out simultaniously. Effectiveness of this combination therapy was found to be 17/18 (94%), being seen in every grade of severity, namely mild, moderate, and severe one, and also recognized those effect in every extent of this disease, such as proctitis, leftside-colitis, and entire-colitis. Adverse effects were recognized as following; local irritability in 5 cases, discomfort over lower abdomen in one case, pain over lower abdomen in one case.<BR>It was suggested that the combined administration of oarl and topical SASP for the treatment of ulcerative colitis was very effective.
日本大腸肛門病学会の論文