THE EFFECTS OF CHOLECYSTOKININ, CAERULEIN AND ENDOGENOUS CHOLECYSTOKININ ON THE MOVEMENT OF THE PAPILLARY REGION

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The movement of the papillary region was measured by means of a pressure sensor, and the changes of the movement by gastrointestinal hormones were studied in rabbit.After the intravenous administration of CCK-PZ (4-8u/kg/3min) the movement of the papillary region was accelerated immediately. On the other hand, during the administration of CCK-PZ (0.5, 1 and 2u/kg/hr) in comparison with those of control pattern, the movement was depressed gradually.After the administration of caerulein (300ng/kg/3min) the movement was accelerated immediately as well as CCK-PZ. During the intravenous administration of caerulein with dose 100, 500ng/kg/hr the movement was accelerated gradually.The action of cholecystokinin on the papillary region was inhibited by secretin, but was not inhibited by atropin-administration and surgical vagotomy.About 15-60 minutes later, after duodenal amino-acids or olive oil perfusion, the elongation of wave length was observed in the dog. The effect of these hormones on the movement of the papillary region was mesured by the pressure sensor using a duodenofiberscope in man. After the administration of CCK-PZ (1-2u/kg/3min), the deterioration of the movement of papillary region was observed, then 6-7 minutes later, the movement was accelerated. At the same time, bile excretion was revealed under the direct vision by duodenofiberscope.
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