ENDOCRINE EFFECTS ON PLASMA CALCIUM IN PARATHYROIDECTOMIZED RATS
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概要
- 論文の詳細を見る
Endocrine effects on plasma calcium was studied in parathyroidectomized rats. Male Wistar rats parathyroidectomized by hot wire cautery were immediately given various hormonal preparations subcutaneously. In some animals adrenalectomy or thyroidectomy was performed immediately before parathyroidectomy. Blood samples were taken 6hrs. later and the plasma calcium was determined by EDTA titration method. A significant elevation of plasma calcium was observed after thyroidectomy or adrenalectomy, while a decrease in plasma calcium was found after subcutaneous injection of cortisol. No significant change of plasma calcium was seen after subcutaneous injection of ACTH, TSH, GH, lysine vasopressin, LH, corticosterone, noradrenaline, adrenaline, insulin and estrogen. Correlative investigation was further performed to compare the effects of the adrenal and thyroid on calcium metabolism with the emphasis on the hypocalcemic effect of cortisol. It was suggested that the hypocalcemic effect of cortisol was mainly due to the inhibition of intestinal absorption of calcium and not mediated by the secretion of thyrocalcitonin.
- 社団法人 日本内分泌学会の論文
著者
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Fujita Takuo
Department of Internal Medicine, Kobe University School of Medicine
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Yoshikawa Masaki
Department Of Cardiology Tsuyama Center Hospital
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Orimo Hajime
Department Of Endocrinology Tokyo Metropolitan Geriatric Medical Center
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Fujita Takuo
Department Of Internal Medicine Kobe University School Of Medicine
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Orimo Hajime
Department of Geriatrics, Faculty of Medicine, University of Tokyo
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FUJITA TAKUO
Department of Geriatrics, Faculty of Medicine, University of Tokyo
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FUJITA TAKUO
Department of Anatomy, Jikei University School of Medicine
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ORIMO HAJIME
Department of Endocrinology and Metabolism, Tokyo Metropolitan Geriatric Hospital
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