Effect of Tetragastrin on Calcium Absorption from Rat Duodenal Loop in vivo

概要

論文の詳細を見る
Calcium absorption from rat duodenal loop was measured in vivo by placing 0.2 mg Ca as CaCl2 solution with or without 47Ca into the loop, followed by measurement of the decrease of Ca and/or 47Ca in the loop. Synthetic tetragastrin, 10-40μg/kg body weight, administered subcutaneously immediately before placing Ca solution in the loop, stimulated calcium absorption from the loop in intact rats, but not in animals parathyroidectomized or thyroparathyroidectomized 24hr prior to the experiment. Stimulating effect of tetragastrin on calcium absorption from the intestinal loop thus appears to require intact parathyroid. Acidification of the loop content failed to influence the calcium absorption from the loop, so that the effect of tetragastrin is probably not mediated by acid secretion. Since gastrin is secreted in response to calcium load and calcitonin release is stimulated by gastrin, these two hormones appear to form a functional unit to maintain calcium homeostasis, especially on the basis of this new property of gastrin increasing calcium absorption.
社団法人日本内分泌学会の論文