Effect of Calcitonin on the Development of Immobilization Osteoporosis in Rat
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概要
- 論文の詳細を見る
The inhibitory effect of porcine calcitonin on the development of immobilization osteoporosis was studied in rat through the analysis of calcium and collagen content of the femur and tibia and the measurement of cortical thickness of the femur. A marked decrease in the calcium content of the femur and collagen content of the tibia of the right hind limb immobilized through the application of a plaster cast was slightly but significantly inhibited by the simultaneous s.c. injection of either 50 MRCmU or 200 MRCmU of porcine calcitonin. However, calcitonin failed to show any effect against the decrease in the cortical thickness of the femur of the immobilized limbs of rats.<BR>It is concluded that calcitonin diminishes the effect of immobilization on the development of osteoporosis possibly through the inhibition of bone resorption.
- 社団法人 日本内分泌学会の論文
著者
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Fujita Takuo
Department of Internal Medicine, Kobe University School of Medicine
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Yoshikawa Masaki
Department Of Cardiology Tsuyama Center Hospital
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Orimo Hajime
Department Of Endocrinology Tokyo Metropolitan Geriatric Medical Center
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Fujita Takuo
Department Of Internal Medicine Kobe University School Of Medicine
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FUJITA TAKUO
Department of Anatomy, Jikei University School of Medicine
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ORIMO HAJIME
Department of Endocrinology and Metabolism, Tokyo Metropolitan Geriatric Hospital
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