Pyrophosphate Enhancement of Thyrocalcitonin Effect in Tissue Culture
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概要
- 論文の詳細を見る
<I>In vitro</I> bone culture technique was developed by the modification of the Goldhabers method. Using this method, pyrophosphate was found to inhibit PTH induced bone resorption as judged by the release of previously incorporated Ca<SUP>45</SUP> into the medium and by the histological findings. Furthermore, addition of pyrophosphate markedly enhanced the thyrocalcitonin inhibition of bone resorption in this system. These findings, together with the previous findings that pyrophosphate enhances the hypocalcemic response to TC <I>in vivo</I>, strongly suggest the favorable effect of the combined use of pyrophosphate and TC in the bone diseases characterized by excessive bone resorption.
- 社団法人 日本内分泌学会の論文
著者
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Fujita Takuo
Department of Internal Medicine, Kobe University School of Medicine
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Yoshikawa Masaki
Department Of Cardiology Tsuyama Center Hospital
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Orimo Hajime
Department Of Endocrinology Tokyo Metropolitan Geriatric Medical Center
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Fujita Takuo
Department Of Internal Medicine Kobe University School Of Medicine
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