Parathyroid Hormono-hydrolyzing Enzymes in Human Kidney
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概要
- 論文の詳細を見る
Human kidney tissue obtained at autopsy was homogenized in 0.15M KCl and centrifuged at 600 or 100, 000g to test the supernatants for the activity of hydrolyzing <SUP>125</SUP>Ilabelled bovine parathyroid hormone through incubation at 37°C for 1 hour and measurement of trichloroacetic acid-soluble <SUP>125</SUP>I released. PTH-hydrolyzing activity was apparently soluble and mainly located in the supernatant fraction of centrifugation at 100, 000 with the optimal pH of 4.5, unlike the rat kidney microsomal parathyroid hormone-hydrolyzing enzyme with optimal pH of 8.5. The activity per unit tissue weight slightly increased with advance in age but the total activity in both kidneys decreased with advance in age.
- 社団法人 日本内分泌学会の論文
著者
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Yoshikawa Masaki
Department Of Cardiology Tsuyama Center Hospital
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Orimo Hajime
Department Of Endocrinology Tokyo Metropolitan Geriatric Medical Center
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Fujita Takuo
Department Of Internal Medicine Kobe University School Of Medicine
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