PREVENTION OF EXPERIMENTAL BONE ATROPHY BY THYROCALCITONIN

概要

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In order to study the effect of thyrocalcitonin on experimental bone atrophy, male Wistar rats were placed on low calcium diet and given prednisol one twice a week. Thyrocalcitonin administered in a dose of 50 MRC milliunits in a single subcutaneous injection daily caused an increase of cortical thickness of the femur and tibia and slight increase in the weight of tibia and specific gravity of both bones, but calcium and phosphorus content failed to show a marked change. Upon incubation of the metaphysis and diaphysis of the femur in Krebs Ringer bicarbonate buffer p H 7.4 containing <SUP>45</SUP>Ca at 37°Cfor 1 hr., a significant inhibition of <SUP>45</SUP>Ca uptake by the metaphysis of the femur was seen in thyrocalcitonin-treated rats. Maximal weight before breaking upon bending stress was also increased in thyrocalcitonin treated rats. These findings are consistent with the preventive effect of thyrocalcitonin on experimental bone atrophy probably through inhibition of bone resorption.
社団法人日本内分泌学会の論文