Effects of 1α-Hydroxyvitamin D<SUB>3</SUB> on Experimental Uremic Renal Osteodystrophy in Rats Induced by Na-Sulfacetylthiazole
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概要
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Na-sulfacetylthiazole (SAT), 0.1g/kg body weight as 5% aqueous solution, was injected intraperitoneally to Wistar male rats weighing 200 to 300g, twice a week for 1, 2 and 4 months, while 1 α-hydroxy vitamin D<SUB>3</SUB> (1α-OH-D<SUB>3</SUB>) was simultaneously administered orally to a half of the SAT-4 month-treated rats at a daily dose of 0.25αg/kg body weight for the last 19 days of the feeding period. Both blood urea nitrogen (BUN) and serum inorganic phosphorus concentrations were markedly increased and the histological examination of the kidneys of SAT-treated rats revealed interstitial nephritis. Serum calcium level was significantly decreased in the rats treated with SAT for 2 or 4 months. Serum parathyroid hormone (PTH) level as well as the wet weight of parathyroid glands was increased in SAT-treated rats, while simultaneous administration of la-OH-D<SUB>3</SUB> inhibited such increases. Serum 25-hydroxyvitamin D<SUB>3</SUB> (25-OH-D<SUB>3</SUB>) was decreased in the rats treated with SAT for 2 months. The X-ray density and calcium content of the femurs of SAT-treated rats were decreased, while simultaneous administration of lα-OH-D<SUB>3</SUB> inhibited such decreases. Tetrachrome stain of the femurs of SAT-4 month-treated rats revealed a marked increase of osteoid contents in the bone cortex, while 1α-OH-D<SUB>3</SUB> inhibited such an increase in osteoid formation. These data indicate that 1α-OH-D<SUB>3</SUB> would be effective for the treatment of uremic renal osteodystrophy, although its detailed mechanism remains to be further clarified.
- 社団法人 日本内分泌学会の論文
著者
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Yoshikawa Masaki
Department Of Cardiology Tsuyama Center Hospital
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OKANO KAZUTOSHI
Department of Geriatrics, University of Tokyo Faculty of Medicine
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NAKAI RUMIKO
Department of Geriatrics, Faculty of Medicine, University of Tokyo
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TOMORI TAKASHI
Department of Geriatrics, Faculty of Medicine, University of Tokyo
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OKANO KAZUTOSHI
Department of Geriatrics, Faculty of Medicine, University of Tokyo
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