Endocrine Factors in Senile Osteoporosis
スポンサーリンク
概要
- 論文の詳細を見る
Serum 1, 25-dihydroxyvitamin D [1, 25 (OH) <SUB>2</SUB>D], parathyroid hormone (PTH), calcitonin (CT), calcium, inorganic phosphorus and alkaline phosphatase (Al-Pase) levels were determined in 24 patients with senile or postmenopausal osteoporosis, which was diagnosed by lateral X-ray film of lumbar vertebrae and divided into 3 stages, porosis score I, II and III according to its severity. Serum calcium in osteoporotic group with porosis score II or III was within normal limits but significantly increased compared to that of the age-matched normal group. There was no significant difference in serum inorganic phosphorus and serum Al-Pase levels between osteoporotic groups and age-matched normal group. Serum 1, 25 (OH) <SUB>2</SUB>D level determined by radioreceptor assay was significantly decreased in the osteoporotic group with porosis score III compared to that of normal group. Serum PTH was supernomal or higher than normal level in all of osteoporotic groups, while serum CT was within normal limits in those osteoporotic groups. There was no significant correlation among serum 1, 25 (OH) <SUB>2</SUB>D, PTH and CT or between any of these calcium-regulating hormones and serum calcium, inorganic phosphorus and Al-Pase, either in osteoporotic groups or in normal group. From these results, it is presumable that a decrease in serum 1, 25 (OH) <SUB>2</SUB>D is not the only factor for the pathogenesis of senile osteoporosis, and some abnormality in the receptors of the target organs to 1, 25 (OH) <SUB>2</SUB>D<SUB>3</SUB> or some other factor than 1, 25 (OH) <SUB>2</SUB>D<SUB>3</SUB> might be playing a role for an increase of serum PTH level leading to an increase of bone resorption.
- 社団法人 日本内分泌学会の論文
著者
-
OKANO KAZUTOSHI
Department of Geriatrics, University of Tokyo Faculty of Medicine
-
NAKAI RUMIKO
Department of Geriatrics, Faculty of Medicine, University of Tokyo
-
HARASAWA MICHIYOSHI
Department of Geriatrics, University of Tokyo Faculty of Medicine
関連論文
- Effect of Parathyroidectomy on Bone Atrophy Induced by Renal Injury with Na-Sulfacetylthiazole
- Effect of Renal Injury on the Activity of Enzymes Preferentially Hydrolyzing Parathyroid Hormone
- A Case of Pseudohypoparathyroidism with Increased Bone Turnover and Demineralization
- Effects of 1α-Hydroxyvitamin D3 on Experimental Uremic Renal Osteodystrophy in Rats Induced by Na-Sulfacetylthiazole
- Effects of Age and Diseases on Human Serum 25-Hydroxycholecalcif erol Determined by Competitive Protein-Binding Assay
- Endocrine Factors in Senile Osteoporosis
- Physiological Significance of an Enzyme Preferentially Hydrolyzing Parathyroid Hormone in Rat Kidney
- Endocrine Control of the Intestinal Calcium Excretion
- A Radioimmunoassay for Rat Serum Parathyroid Hormone using N-terminal of PTH
- Differential Hydrolysis of Bovine Parathyroid Hormone and its N-terminal Peptide by Rat Kidney
- Radioimmunoassay of Serum Parathyroid Hormone in Postmenopausal Osteoporosis