生体膜の物質透過に関する基礎的研究-3-ケファリン-コレステロール混成膜の異常浸透性について

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In the previous paper1), the authors made a report on the results of studies on anomalous osmosis through cephalin- and cholesterol-membranes with different salt and acid solutions. In the present paper, the anomalous osmosis through the mixed membrane reconstructed with cephalin and cholesterol was measured with different salt and acid solutions. They also compared the osmosis with that through cephalin- and cholesterol-membranes in the previous paper1), respectively. The results obtained were as follows: Anomalous positive osmosis of K-chloride, K-sulfate, K-citrate, Na-chloride, Na-gluta-mate, sulfuric acid and acetic acid through the mixed membrane was smaller than that with the above-mentioned solutions through cephalin-membrane. However, anomalous osmosis of Mg-sulfate, hydrochloric acid, L-glutamic acid and gly-cine through the mixed membrane showed negative osmosis whereas those through cephalin-membrane showed positive one. Anomalous negative osmosis of Ca-chloride and Mg-chloride was almost of the same order with both cephalin- and mixed membranes. Anomalous osmosis of K-chloride, Na-chloride, Mg-chloride and sucrose was almost of the same order with both mixed and cholesterol-membranes, but with K-sulfate and K-citrate, osmosis through the mixed membrane was larger than that through cholesterol-membrane. From the facts mentioned above, the authors may reasonably suggest that cholesterol plays the major role controlling the transport of water through cephalin-menbrane.
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生体膜の物質透過に関する基礎的研究-3-ケファリン-コレステロール混成膜の異常浸透性について

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