C型肝炎に対するmterferonの短期投与の抗ウイルス効果

概要

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We have assayed HCV RNA levels, anti-CP-9 and anti-C100-3 in serial serum samples from 12 patients with chronic hepatitis C who were treated with short term (4-6 weeks) interfelon. In six patients, serum ALT levels fell to normal and remained in normal range after termination of treatment (effective group). The ALT levels did not improve in other six patients (non-effective group).<BR>Serum HCV RNA decreased markedly in all patients belonged to both groups at the end of treatment. In effective group. HCV RNA in serum sustained (-) or (+) after stopping interferon, but HCV RNA in serum returned gradually or rapidly to pre-treatment levels ( - ) in non-effective group. These observations suggest that interferon seems to suppress HCV RNA in serum and interferon treatment may improve natural course of chronic hepatitis C.